Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine.
Multidrug-resistant falciparum malaria is a major health problem along the Thai-Burmese border. From July 1985 until December 1986 a total of 5192 patients with falciparum malaria (1734 males, 3458 females) from this area were given supervised treatment with the combination mefloquine-sulfadoxine-py...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1987
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| _version_ | 1797072312356306944 |
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| author | Nosten, F Imvithaya, S Vincenti, M Delmas, G Lebihan, G Hausler, B White, N |
| author_facet | Nosten, F Imvithaya, S Vincenti, M Delmas, G Lebihan, G Hausler, B White, N |
| author_sort | Nosten, F |
| collection | OXFORD |
| description | Multidrug-resistant falciparum malaria is a major health problem along the Thai-Burmese border. From July 1985 until December 1986 a total of 5192 patients with falciparum malaria (1734 males, 3458 females) from this area were given supervised treatment with the combination mefloquine-sulfadoxine-pyrimethamine (MSP). The radical cure rate, assessed 21 days after drug administration, was 98.4% for the first 1975 patients, and 98.8% when assessed at 28 days for the remaining 3217 patients. In 3.8% of cases, parasites were still detected in peripheral blood smears on day 7 after treatment but this had fallen to 0.27% by day 9. Adverse reactions among the first 1975 patients were: vertigo (7.5% of patients), vomiting (5.8%), epigastric pain (0.6%), and transient confusional state (one case). MSP is an effective and well-tolerated drug for the treatment of drug-resistant falciparum malaria; however, delayed parasite clearance may give a false impression of RII resistance. |
| first_indexed | 2024-03-06T23:05:58Z |
| format | Journal article |
| id | oxford-uuid:63cd8a3f-2b85-493e-a51c-63e5c18daf3e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:05:58Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:63cd8a3f-2b85-493e-a51c-63e5c18daf3e2022-03-26T18:15:15ZMalaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:63cd8a3f-2b85-493e-a51c-63e5c18daf3eEnglishSymplectic Elements at Oxford1987Nosten, FImvithaya, SVincenti, MDelmas, GLebihan, GHausler, BWhite, NMultidrug-resistant falciparum malaria is a major health problem along the Thai-Burmese border. From July 1985 until December 1986 a total of 5192 patients with falciparum malaria (1734 males, 3458 females) from this area were given supervised treatment with the combination mefloquine-sulfadoxine-pyrimethamine (MSP). The radical cure rate, assessed 21 days after drug administration, was 98.4% for the first 1975 patients, and 98.8% when assessed at 28 days for the remaining 3217 patients. In 3.8% of cases, parasites were still detected in peripheral blood smears on day 7 after treatment but this had fallen to 0.27% by day 9. Adverse reactions among the first 1975 patients were: vertigo (7.5% of patients), vomiting (5.8%), epigastric pain (0.6%), and transient confusional state (one case). MSP is an effective and well-tolerated drug for the treatment of drug-resistant falciparum malaria; however, delayed parasite clearance may give a false impression of RII resistance. |
| spellingShingle | Nosten, F Imvithaya, S Vincenti, M Delmas, G Lebihan, G Hausler, B White, N Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title | Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title_full | Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title_fullStr | Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title_full_unstemmed | Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title_short | Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. |
| title_sort | malaria on the thai burmese border treatment of 5192 patients with mefloquine sulfadoxine pyrimethamine |
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