Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2010
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| _version_ | 1826275924741455872 |
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| author | Yindom, L Leligdowicz, A Martin, M Gao, X Qi, Y Zaman, S van der Loeff, MS van Tienen, C Jaye, A Aveika, A Worwui, A Diatta, M Vincent, T Whittle, H Rowland-Jones, S Walton, R Carrington, M |
| author_facet | Yindom, L Leligdowicz, A Martin, M Gao, X Qi, Y Zaman, S van der Loeff, MS van Tienen, C Jaye, A Aveika, A Worwui, A Diatta, M Vincent, T Whittle, H Rowland-Jones, S Walton, R Carrington, M |
| author_sort | Yindom, L |
| collection | OXFORD |
| description | Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course. |
| first_indexed | 2024-03-06T23:06:13Z |
| format | Journal article |
| id | oxford-uuid:63e3ab8c-2a13-4c59-a66c-e567d994cdd5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:06:13Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:63e3ab8c-2a13-4c59-a66c-e567d994cdd52022-03-26T18:15:46ZInfluence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:63e3ab8c-2a13-4c59-a66c-e567d994cdd5EnglishSymplectic Elements at Oxford2010Yindom, LLeligdowicz, AMartin, MGao, XQi, YZaman, Svan der Loeff, MSvan Tienen, CJaye, AAveika, AWorwui, ADiatta, MVincent, TWhittle, HRowland-Jones, SWalton, RCarrington, MOverall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course. |
| spellingShingle | Yindom, L Leligdowicz, A Martin, M Gao, X Qi, Y Zaman, S van der Loeff, MS van Tienen, C Jaye, A Aveika, A Worwui, A Diatta, M Vincent, T Whittle, H Rowland-Jones, S Walton, R Carrington, M Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title | Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title_full | Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title_fullStr | Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title_full_unstemmed | Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title_short | Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. |
| title_sort | influence of hla class i and hla kir compound genotypes on hiv 2 infection and markers of disease progression in a manjako community in west africa |
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