Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcriptional activity. FIH also catalyzes the hydroxylati...

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Bibliographic Details
Main Authors:	Yang, M, Ge, W, Chowdhury, R, Claridge, T, Kramer, H, Schmierer, B, McDonough, M, Gong, L, Kessler, B, Ratcliffe, P, Coleman, M, Schofield, C
Format:	Journal article
Language:	English
Published:	2011

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