Reconciling transport models across scales: The role of volume exclusion
Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into account the role of volume exclusion, which can significantly alter diffusi...
| Main Authors: | , , , |
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| Format: | Journal article |
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American Physical Society
2015
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| _version_ | 1797072351873990656 |
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| author | Taylor, P Yates, C Simpson, M Baker, R |
| author_facet | Taylor, P Yates, C Simpson, M Baker, R |
| author_sort | Taylor, P |
| collection | OXFORD |
| description | Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into account the role of volume exclusion, which can significantly alter diffusive transport, particularly within biological systems where the diffusing particles might occupy a significant fraction of the available space. In this work we use a random walk approach to provide a means to reconcile models that incorporate crowding effects on different spatial scales. Our work demonstrates that coarse-grained models incorporating simplified descriptions of excluded volume can be used in many circumstances, but that care must be taken in pushing the coarse-graining process too far. |
| first_indexed | 2024-03-06T23:06:33Z |
| format | Journal article |
| id | oxford-uuid:640503ac-a537-47af-b841-3e8782ddbc42 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:06:33Z |
| publishDate | 2015 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:640503ac-a537-47af-b841-3e8782ddbc422022-03-26T18:16:27ZReconciling transport models across scales: The role of volume exclusionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:640503ac-a537-47af-b841-3e8782ddbc42Symplectic Elements at OxfordAmerican Physical Society2015Taylor, PYates, CSimpson, MBaker, RDiffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into account the role of volume exclusion, which can significantly alter diffusive transport, particularly within biological systems where the diffusing particles might occupy a significant fraction of the available space. In this work we use a random walk approach to provide a means to reconcile models that incorporate crowding effects on different spatial scales. Our work demonstrates that coarse-grained models incorporating simplified descriptions of excluded volume can be used in many circumstances, but that care must be taken in pushing the coarse-graining process too far. |
| spellingShingle | Taylor, P Yates, C Simpson, M Baker, R Reconciling transport models across scales: The role of volume exclusion |
| title | Reconciling transport models across scales: The role of volume exclusion |
| title_full | Reconciling transport models across scales: The role of volume exclusion |
| title_fullStr | Reconciling transport models across scales: The role of volume exclusion |
| title_full_unstemmed | Reconciling transport models across scales: The role of volume exclusion |
| title_short | Reconciling transport models across scales: The role of volume exclusion |
| title_sort | reconciling transport models across scales the role of volume exclusion |
| work_keys_str_mv | AT taylorp reconcilingtransportmodelsacrossscalestheroleofvolumeexclusion AT yatesc reconcilingtransportmodelsacrossscalestheroleofvolumeexclusion AT simpsonm reconcilingtransportmodelsacrossscalestheroleofvolumeexclusion AT bakerr reconcilingtransportmodelsacrossscalestheroleofvolumeexclusion |