Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
Aromatic analogues of the 2-oxoglutarate cosubstrate of the hypoxia-inducible factor hydroxylases are shown to bind at the active site iron: Pyridine-2,4-dicarboxylate binds as anticipated with a single molecule chelating the iron in a bidentate manner. The binding mode of a hydroxamic acid analogue...
Full description
Bibliographic Details
| Main Authors: |
Conejo-Garcia, A,
McDonough, M,
Loenarz, C,
Schofield, C,
Clifton, I |
|---|
| Other Authors: |
McNeill, L |
|---|
| Format: | Journal article
|
|---|
| Language: | English |
|---|
| Published: |
Elsevier
2010
|
|---|
| Subjects: | |
|---|