Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
Aromatic analogues of the 2-oxoglutarate cosubstrate of the hypoxia-inducible factor hydroxylases are shown to bind at the active site iron: Pyridine-2,4-dicarboxylate binds as anticipated with a single molecule chelating the iron in a bidentate manner. The binding mode of a hydroxamic acid analogue...
| Main Authors: | , , , , |
|---|---|
| 其他作者: | |
| 格式: | Journal article |
| 語言: | English |
| 出版: |
Elsevier
2010
|
| 主題: |