Prostate volume and its correlation with histopathological outcomes in prostate cancer.
INTRODUCTION: There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. PATIENTS AND METHODS: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1826276004675452928 |
|---|---|
| author | Sooriakumaran, P Srivastava, A Bhagat, D John, M Grover, S El-Douaihy, Y Rajan, S Leung, R Tewari, A |
| author_facet | Sooriakumaran, P Srivastava, A Bhagat, D John, M Grover, S El-Douaihy, Y Rajan, S Leung, R Tewari, A |
| author_sort | Sooriakumaran, P |
| collection | OXFORD |
| description | INTRODUCTION: There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. PATIENTS AND METHODS: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm(3)), intermediate (40-70 cm(3)), and large (>70 cm(3)) prostate groups. RESULTS: Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. CONCLUSIONS: Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates. |
| first_indexed | 2024-03-06T23:07:27Z |
| format | Journal article |
| id | oxford-uuid:6455fb6b-e98b-4ca6-acb4-73855543c80e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:07:27Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:6455fb6b-e98b-4ca6-acb4-73855543c80e2022-03-26T18:18:19ZProstate volume and its correlation with histopathological outcomes in prostate cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6455fb6b-e98b-4ca6-acb4-73855543c80eEnglishSymplectic Elements at Oxford2011Sooriakumaran, PSrivastava, ABhagat, DJohn, MGrover, SEl-Douaihy, YRajan, SLeung, RTewari, A INTRODUCTION: There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. PATIENTS AND METHODS: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm(3)), intermediate (40-70 cm(3)), and large (>70 cm(3)) prostate groups. RESULTS: Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. CONCLUSIONS: Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates. |
| spellingShingle | Sooriakumaran, P Srivastava, A Bhagat, D John, M Grover, S El-Douaihy, Y Rajan, S Leung, R Tewari, A Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title | Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title_full | Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title_fullStr | Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title_full_unstemmed | Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title_short | Prostate volume and its correlation with histopathological outcomes in prostate cancer. |
| title_sort | prostate volume and its correlation with histopathological outcomes in prostate cancer |
| work_keys_str_mv | AT sooriakumaranp prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT srivastavaa prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT bhagatd prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT johnm prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT grovers prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT eldouaihyy prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT rajans prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT leungr prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer AT tewaria prostatevolumeanditscorrelationwithhistopathologicaloutcomesinprostatecancer |