Blockade of CTLA-4 promotes the development of effector CD8(+) T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8(+) T lymphocytes that efficiently prevent tumor develo...
Πλήρης περιγραφή
Λεπτομέρειες βιβλιογραφικής εγγραφής
| Κύριοι συγγραφείς: |
Dos Santos, L,
Galvão-Filho, B,
de Faria, P,
Junqueira, C,
Dutra, MS,
Teixeira, S,
Rodrigues, M,
Ritter, G,
Bannard, O,
Fearon, D,
Antonelli, L,
Gazzinelli, RT |
|---|
| Μορφή: | Journal article
|
|---|
| Γλώσσα: | English |
|---|
| Έκδοση: |
Springer Berlin Heidelberg
2015
|
|---|