The hydration of the neurotransmitter acetylcholine in aqueous solution.
Neutron diffraction augmented with hydrogen isotope substitution has been used to examine the water structure around the acetylcholine molecular ion in aqueous solution. It is shown that the nearest-neighbor water molecules in the region around the trimethylammonium headgroup are located either in a...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1826276015212593152 |
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| author | Hulme, E Soper, A McLain, SE Finney, J |
| author_facet | Hulme, E Soper, A McLain, SE Finney, J |
| author_sort | Hulme, E |
| collection | OXFORD |
| description | Neutron diffraction augmented with hydrogen isotope substitution has been used to examine the water structure around the acetylcholine molecular ion in aqueous solution. It is shown that the nearest-neighbor water molecules in the region around the trimethylammonium headgroup are located either in a ring around the central nitrogen atom or between the carbon atoms, forming a sheath around the onium group. Moreover the water molecules in this cavity do not bond to the onium group but rather form hydrogen bonds with water molecules in the surrounding aqueous environment. Given that in the bound state the onium headgroup must be completely desolvated, the absence of bonding between the onium headgroup and the surrounding water solvent may be selectively favorable to acetylcholine-binding in the receptor site. Away from the headgroup, pronounced hydrogen-bonding of water to the carbonyl oxygen is observed, but not to the ether oxygen in the acetylcholine chain. |
| first_indexed | 2024-03-06T23:07:37Z |
| format | Journal article |
| id | oxford-uuid:64619d2d-2335-4131-a673-9ffd208eb120 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:07:37Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:64619d2d-2335-4131-a673-9ffd208eb1202022-03-26T18:18:35ZThe hydration of the neurotransmitter acetylcholine in aqueous solution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:64619d2d-2335-4131-a673-9ffd208eb120EnglishSymplectic Elements at Oxford2006Hulme, ESoper, AMcLain, SEFinney, JNeutron diffraction augmented with hydrogen isotope substitution has been used to examine the water structure around the acetylcholine molecular ion in aqueous solution. It is shown that the nearest-neighbor water molecules in the region around the trimethylammonium headgroup are located either in a ring around the central nitrogen atom or between the carbon atoms, forming a sheath around the onium group. Moreover the water molecules in this cavity do not bond to the onium group but rather form hydrogen bonds with water molecules in the surrounding aqueous environment. Given that in the bound state the onium headgroup must be completely desolvated, the absence of bonding between the onium headgroup and the surrounding water solvent may be selectively favorable to acetylcholine-binding in the receptor site. Away from the headgroup, pronounced hydrogen-bonding of water to the carbonyl oxygen is observed, but not to the ether oxygen in the acetylcholine chain. |
| spellingShingle | Hulme, E Soper, A McLain, SE Finney, J The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title | The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title_full | The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title_fullStr | The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title_full_unstemmed | The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title_short | The hydration of the neurotransmitter acetylcholine in aqueous solution. |
| title_sort | hydration of the neurotransmitter acetylcholine in aqueous solution |
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