Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)
The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dim...
| Hlavní autoři: | , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
Nature Publishing Group UK
2025
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| _version_ | 1826342864979755008 |
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| author | Piccinini, JI Sanz Perl, Y Pallavicini, C Deco, G Kringelbach, M Nutt, D Carhart-Harris, R Timmermann, C Tagliazucchi, E |
| author_facet | Piccinini, JI Sanz Perl, Y Pallavicini, C Deco, G Kringelbach, M Nutt, D Carhart-Harris, R Timmermann, C Tagliazucchi, E |
| author_sort | Piccinini, JI |
| collection | OXFORD |
| description | The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation. Simulated perturbations reveal a transient of heightened reactivity concentrated in fronto-parietal regions and visual cortices, correlated with serotonin 5HT2a receptor density, the primary target of psychedelics. These advances suggest a mechanism to explain key features of the psychedelic state and also predicts that the temporal evolution of these features aligns with pharmacokinetics. Our results contribute to understanding how psychedelics introduce a transient where minimal perturbations can achieve a maximal effect, shedding light on how short psychedelic episodes may extend an overarching influence over time. |
| first_indexed | 2025-03-11T23:38:03Z |
| format | Journal article |
| id | oxford-uuid:6468b02f-f55e-456e-9c8c-bd02d659e0a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-03-11T23:38:03Z |
| publishDate | 2025 |
| publisher | Nature Publishing Group UK |
| record_format | dspace |
| spelling | oxford-uuid:6468b02f-f55e-456e-9c8c-bd02d659e0a42025-03-11T20:26:14ZTransient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6468b02f-f55e-456e-9c8c-bd02d659e0a4EnglishJisc Publications RouterNature Publishing Group UK2025Piccinini, JISanz Perl, YPallavicini, CDeco, GKringelbach, MNutt, DCarhart-Harris, RTimmermann, CTagliazucchi, EThe transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation. Simulated perturbations reveal a transient of heightened reactivity concentrated in fronto-parietal regions and visual cortices, correlated with serotonin 5HT2a receptor density, the primary target of psychedelics. These advances suggest a mechanism to explain key features of the psychedelic state and also predicts that the temporal evolution of these features aligns with pharmacokinetics. Our results contribute to understanding how psychedelics introduce a transient where minimal perturbations can achieve a maximal effect, shedding light on how short psychedelic episodes may extend an overarching influence over time. |
| spellingShingle | Piccinini, JI Sanz Perl, Y Pallavicini, C Deco, G Kringelbach, M Nutt, D Carhart-Harris, R Timmermann, C Tagliazucchi, E Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title | Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title_full | Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title_fullStr | Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title_full_unstemmed | Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title_short | Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) |
| title_sort | transient destabilization of whole brain dynamics induced by n n dimethyltryptamine dmt |
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