The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitope...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1826276041273901056 |
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| author | Addo, M Altfeld, M Rosenberg, E Eldridge, R Philips, M Habeeb, K Khatri, A Brander, C Robbins, G Mazzara, G Goulder, P Walker, B |
| author_facet | Addo, M Altfeld, M Rosenberg, E Eldridge, R Philips, M Habeeb, K Khatri, A Brander, C Robbins, G Mazzara, G Goulder, P Walker, B |
| author_sort | Addo, M |
| collection | OXFORD |
| description | The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines. |
| first_indexed | 2024-03-06T23:08:01Z |
| format | Journal article |
| id | oxford-uuid:64865adc-a49d-44e0-b546-2369c7f87c7a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:08:01Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:64865adc-a49d-44e0-b546-2369c7f87c7a2022-03-26T18:19:24ZThe HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:64865adc-a49d-44e0-b546-2369c7f87c7aEnglishSymplectic Elements at Oxford2001Addo, MAltfeld, MRosenberg, EEldridge, RPhilips, MHabeeb, KKhatri, ABrander, CRobbins, GMazzara, GGoulder, PWalker, BThe HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines. |
| spellingShingle | Addo, M Altfeld, M Rosenberg, E Eldridge, R Philips, M Habeeb, K Khatri, A Brander, C Robbins, G Mazzara, G Goulder, P Walker, B The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title | The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title_full | The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title_fullStr | The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title_full_unstemmed | The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title_short | The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. |
| title_sort | hiv 1 regulatory proteins tat and rev are frequently targeted by cytotoxic t lymphocytes derived from hiv 1 infected individuals |
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