Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.
HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E...
| मुख्य लेखक: | |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2000
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| _version_ | 1826276041678651392 |
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| author | O'Callaghan, C |
| author_facet | O'Callaghan, C |
| author_sort | O'Callaghan, C |
| collection | OXFORD |
| description | HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E. |
| first_indexed | 2024-03-06T23:08:01Z |
| format | Journal article |
| id | oxford-uuid:6486c32e-e10c-4e16-8092-976ee07b1b3c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:08:01Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:6486c32e-e10c-4e16-8092-976ee07b1b3c2022-03-26T18:19:22ZNatural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6486c32e-e10c-4e16-8092-976ee07b1b3cEnglishSymplectic Elements at Oxford2000O'Callaghan, CHLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E. |
| spellingShingle | O'Callaghan, C Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title | Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title_full | Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title_fullStr | Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title_full_unstemmed | Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title_short | Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors. |
| title_sort | natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of hla e and qa 1b by cd94 nkg2 receptors |
| work_keys_str_mv | AT ocallaghanc naturalkillercellsurveillanceofintracellularantigenprocessingpathwaysmediatedbyrecognitionofhlaeandqa1bbycd94nkg2receptors |