The immunological synapse: a molecular machine controlling T cell activation.
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T ce...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1826276054341255168 |
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| author | Grakoui, A Bromley, S Sumen, C Davis, M Shaw, A Allen, P Dustin, M |
| author_facet | Grakoui, A Bromley, S Sumen, C Davis, M Shaw, A Allen, P Dustin, M |
| author_sort | Grakoui, A |
| collection | OXFORD |
| description | The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation. |
| first_indexed | 2024-03-06T23:08:13Z |
| format | Journal article |
| id | oxford-uuid:6494d279-1c68-48b3-802d-8a90a9f0b186 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:08:13Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:6494d279-1c68-48b3-802d-8a90a9f0b1862022-03-26T18:19:50ZThe immunological synapse: a molecular machine controlling T cell activation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6494d279-1c68-48b3-802d-8a90a9f0b186EnglishSymplectic Elements at Oxford1999Grakoui, ABromley, SSumen, CDavis, MShaw, AAllen, PDustin, MThe specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation. |
| spellingShingle | Grakoui, A Bromley, S Sumen, C Davis, M Shaw, A Allen, P Dustin, M The immunological synapse: a molecular machine controlling T cell activation. |
| title | The immunological synapse: a molecular machine controlling T cell activation. |
| title_full | The immunological synapse: a molecular machine controlling T cell activation. |
| title_fullStr | The immunological synapse: a molecular machine controlling T cell activation. |
| title_full_unstemmed | The immunological synapse: a molecular machine controlling T cell activation. |
| title_short | The immunological synapse: a molecular machine controlling T cell activation. |
| title_sort | immunological synapse a molecular machine controlling t cell activation |
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