PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator-1α (PGC-1α) is a cofactor for transcription factors including the peroxisome proliferator-activated receptor-γ (PPARγ)...

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Bibliographic Details
Main Authors:	Katsouri, L, Lim, Y, Blondrath, K, Eleftheriadou, I, Lombardero, L, Birch, A, Mirzaei, N, Irvine, E, Mazarakis, N, Sastre, M
Format:	Journal article
Published:	National Academy of Sciences 2016

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