INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects.
AIMS: To elucidate the relationship between the human insulin gene INS VNTR regulatory polymorphism and insulin secretion. The polymorphism arises from tandem repetition of 14-15 bp oligonucleotides. In Caucasians, repeat number varies from 26 to over 200, with two main and discrete allele size clas...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797072480186138624 |
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| author | Ahmed, S Bennett, S Huxtable, S Todd, J Matthews, DR Gough, S |
| author_facet | Ahmed, S Bennett, S Huxtable, S Todd, J Matthews, DR Gough, S |
| author_sort | Ahmed, S |
| collection | OXFORD |
| description | AIMS: To elucidate the relationship between the human insulin gene INS VNTR regulatory polymorphism and insulin secretion. The polymorphism arises from tandem repetition of 14-15 bp oligonucleotides. In Caucasians, repeat number varies from 26 to over 200, with two main and discrete allele size classes: class I (26-63 repeats) and class III (141-209 repeats). Class I allele homozygosity is associated with elevated risk of developing Type 1 diabetes, while the class III allele has been associated with increased risk of Type 2 diabetes, polycystic ovary syndrome (PCOS) and with larger size at birth, which may influence development of adult disease. METHODS: Thirty-one healthy adult subjects with normal glucose tolerance, underwent an intravenous glucose tolerance test with one minute sampling. Seventeen subjects were homozygous for class I alleles (14 excluding individuals carrying alleles associated with parent-of-origin effects and heterogeneity in allele transmission) and 14 homozygous for class III alleles. The groups were well matched. RESULTS: No significant differences in amount or rate of insulin secretion, or beta cell function were detected between the two groups. There was a difference in pattern of pulsatile insulin secretion with more 9-minute oscillations in class I homozygotes (P<0.026). The after-load glucose concentration was also higher in subjects with class I alleles (P<0.03). CONCLUSIONS: These results warrant further analysis of possible association between allelic variation of the INS VNTR and the pulsatility of insulin secretion. |
| first_indexed | 2024-03-06T23:08:17Z |
| format | Journal article |
| id | oxford-uuid:649afa28-4752-41ef-a189-091a83da97c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:08:17Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:649afa28-4752-41ef-a189-091a83da97c52022-03-26T18:20:03ZINS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:649afa28-4752-41ef-a189-091a83da97c5EnglishSymplectic Elements at Oxford1999Ahmed, SBennett, SHuxtable, STodd, JMatthews, DRGough, SAIMS: To elucidate the relationship between the human insulin gene INS VNTR regulatory polymorphism and insulin secretion. The polymorphism arises from tandem repetition of 14-15 bp oligonucleotides. In Caucasians, repeat number varies from 26 to over 200, with two main and discrete allele size classes: class I (26-63 repeats) and class III (141-209 repeats). Class I allele homozygosity is associated with elevated risk of developing Type 1 diabetes, while the class III allele has been associated with increased risk of Type 2 diabetes, polycystic ovary syndrome (PCOS) and with larger size at birth, which may influence development of adult disease. METHODS: Thirty-one healthy adult subjects with normal glucose tolerance, underwent an intravenous glucose tolerance test with one minute sampling. Seventeen subjects were homozygous for class I alleles (14 excluding individuals carrying alleles associated with parent-of-origin effects and heterogeneity in allele transmission) and 14 homozygous for class III alleles. The groups were well matched. RESULTS: No significant differences in amount or rate of insulin secretion, or beta cell function were detected between the two groups. There was a difference in pattern of pulsatile insulin secretion with more 9-minute oscillations in class I homozygotes (P<0.026). The after-load glucose concentration was also higher in subjects with class I alleles (P<0.03). CONCLUSIONS: These results warrant further analysis of possible association between allelic variation of the INS VNTR and the pulsatility of insulin secretion. |
| spellingShingle | Ahmed, S Bennett, S Huxtable, S Todd, J Matthews, DR Gough, S INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title | INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title_full | INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title_fullStr | INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title_full_unstemmed | INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title_short | INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. |
| title_sort | ins vntr allelic variation and dynamic insulin secretion in healthy adult non diabetic caucasian subjects |
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