Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.

Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.

OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibrob...

Full description

Bibliographic Details
Main Authors:	Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M
Format:	Journal article
Language:	English
Published:	2000

Similar Items

Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
by: Bondeson, J, et al.
Published: (1999)

Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.
by: Bondeson, J, et al.
Published: (2007)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
by: Kiriakidis, S, et al.
Published: (2003)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
by: Kiriakidis, S, et al.
Published: (2003)

Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.
by: Amos, N, et al.
Published: (2006)

Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.
by: Foxwell, B, et al.
Published: (1998)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
by: Smith, C, et al.
Published: (2001)

Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
by: Yoshimura, S, et al.
Published: (2001)

Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
by: Calder, V, et al.
Published: (2003)

Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
by: Bondeson, J, et al.
Published: (1999)

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
by: Feldmann, M, et al.
Published: (2002)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
by: Andreakos, E, et al.
Published: (2006)

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
by: Williams, L, et al.
Published: (2008)

Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
by: Andreakos, E, et al.
Published: (2003)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
by: Andreakos, E, et al.
Published: (2005)

Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
by: Andreakos, E, et al.
Published: (2003)

Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.
by: Foxwell, B, et al.
Published: (2000)

Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
by: Yoshimura, S, et al.
Published: (2003)

Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
by: Brennan, F, et al.
Published: (2002)

Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes
by: Xiu Zhang, et al.
Published: (2022-01-01)

An NF-kappaB-dependent role for JunB in the induction of proinflammatory cytokines in LPS-activated bone marrow-derived dendritic cells.
by: Tiphanie Gomard, et al.
Published: (2010-01-01)

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
by: Ciesielski, C, et al.
Published: (2002)

NF-kappaB in Lung Tumorigenesis
by: William N. Rom, et al.
Published: (2011-12-01)

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.
by: Benfield, C, et al.
Published: (2011)

Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
by: Sacre, S, et al.
Published: (2007)

The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.
by: Sperone, A, et al.
Published: (2011)

I-KappaB Expression in Patient with Psoriasis Vulgaris
by: Nahed Abdelazeem, et al.
Published: (2022-04-01)

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
by: Alexander, S, et al.
Published: (2007)

Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
by: Bender Patrick, et al.
Published: (2008-07-01)

Visualization of lymphatic vessels through NF-kappaB activity.
by: Saban, MR, et al.
Published: (2004)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
by: Michael Schuliga
Published: (2015-06-01)

Haploid reporter screens aimed at identification of NF-kappaB regulators
by: Lee, Clarissa Ci
Published: (2014)

Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
by: Monaco, C, et al.
Published: (2004)

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
by: Udalova, I, et al.
Published: (2000)

Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.
by: Israf Ali, Daud Ahmad, et al.
Published: (2010)

Cytokine blockade in rheumatoid arthritis.
by: Feldmann, M, et al.
Published: (2001)

NF-kappaB regulates androgen receptor expression and prostate cancer growth.
by: Zhang, L, et al.
Published: (2009)

Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis.
by: Monaco, C, et al.
Published: (2004)

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
by: Brummelkamp, T, et al.
Published: (2003)

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
by: Gyrd-Hansen, M, et al.
Published: (2010)