An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.

BACKGROUND: Phaeochromocytomas and paragangliomas are neuro-endocrine tumours that occur sporadically and in several hereditary tumour syndromes, including the phaeochromocytoma-paraganglioma syndrome. This syndrome is caused by germline mutations in succinate dehydrogenase B (SDHB), C (SDHC), or D...

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Main Authors: van Nederveen, F, Gaal, J, Favier, J, Korpershoek, E, Oldenburg, R, de Bruyn, E, Sleddens, H, Derkx, P, Rivière, J, Dannenberg, H, Petri, B, Komminoth, P, Pacak, K, Hop, W, Pollard, P, Mannelli, M, Bayley, J, Perren, A, Niemann, S, Verhofstad, A, de Bruïne, A, Maher, E, Tissier, F, Méatchi, T, Badoual, C
Format: Journal article
Language:English
Published: 2009