The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?

The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?

The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should matc...

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Detalles Bibliográficos
Autores principales: McMichael, A, Hanke, T
Formato: Journal article
Lenguaje:English
Publicado: 2002
Descripción
Sumario:The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.

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