PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.

PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.

We tested the hypothesis that short-term treatment of mice with Type 2 diabetes mellitus (DM) with rosiglitazone (ROSI), an agonist of peroxisome proliferator-activated receptor-gamma, ameliorates the impaired coronary arteriolar dilation by reducing oxidative stress via a mechanism unrelated to its...

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Xehetasun bibliografikoak
Egile Nagusiak:	Bagi, Z, Koller, A, Kaley, G
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2004

Antzeko izenburuak

PPAR gamma activation restores NO-Mediated dilations of coronary Arterioles in type 2 diabetes Mellitus
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Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus.
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Nitric oxide and hydrogen peroxide contribute to the development of reactive dilation in isolated coronary arterioles
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Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles.
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Hydrogen peroxide elicits COX-2-dependent production of constrictor prostaglandins in arterioles of type 2 diabetic mice
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Increased soluble guanylate cyclase (sGC) activity may compensate for the high fat diet-induced reduction in NO bioavailability of rat coronary arterioles
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Multiple effects of diabetes mellitus on the vasomotor responses of human coronary arterioles
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Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus.
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Role of platelet endothelial adhesion molecule (PECAM)-1 in sensing and mediating high temporal gradients of shear stress in arterioles
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Oxidative stress via activating soluble guanylate cyclase leads to increased nitric oxide sensitivity of coronary arterioles in high fat diet-induced obesity
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PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress.
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Increased activity of tissue ACE impairs dilation of coronary arterioles in obesity
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Conducted vasodilatation in human coronary arterioles
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Enhanced superoxide production reduces NO-mediation of flow-dependent dilation of isolated coronary arteries in type 2 diabetes mellitus
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High intraluminal pressure reduces tachyphylaxis to angiotensin II in isolated arterioles
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Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
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PPAR gamma activation improves wall shear stress dependent regulation of coronary arteriolar diameter in type 2 diabetes mellitus
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Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia.
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Impaired flow-induced dilation in skeletal muscle arterioles of rats with hyperhomocysteinemia (HHCY). Role of nitric oxide and constrictor prostanoids.
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Increased PGH(2)/TXA(2) synthesis in isolated arterioles and platelets of rats with hyperhomocysteinemia (HHCY).
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Tetrahydrobiopterin (BH4) is essential for NO-mediated flow-dependent dilation of isolated skeletal muscle arterioles
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Asymmetric dimethylarginine (ADMA) increases the myogenic tone of arterioles due to enhanced release of superoxide
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Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.
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Type 2 diabetic mice have increased blood pressure and enhanced arteriolar basal tone due to COX-2-dependent TxA(2)/PGH(2) production
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Intrinsic vascular mechanisms stimulated by changes in pressure and now elicit reactive dilatation of isolated arterioles
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Lack of flow-mediated dilation and enhanced angiotensin II-induced constriction in skeletal muscle arterioles of lupus-prone autoimmune mice.
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Upregulation of Arginase I Reduces Nitric Oxide-mediated Coronary Arteriolar Dilation in Patients With Type 2 Diabetes
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Specific roles of COX-1 and COX-2 inhibitors to interfere with the regulation of microvascular resistance in normal mice and mice with type 2 diabetes mellitus
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High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.
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Oxidative stress contributes significantly to the development of cardiac pump dysfunction in hyperhomocysteinemia
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Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).
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Chronic renal failure leads to reduced flow-dependent dilation in isolated rat skeletal muscle arterioles due to lack of NO mediation.
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O-Linked-n-Acetylglucosamine Formation Reduces Nitric Oxide-Dependent Dilation in Arterioles Exposed to High Glucose Concentrations
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H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice.
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Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins.
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Transient elevation of glucose concentration reduces NO-mediation of flow-induced arteriolar dilation due to interaction between superoxide and tetrahydrobiopterin (BH4)
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Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats
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Fatty acid metabolism in patients with PPARgamma mutations.
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