PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.

PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.

We tested the hypothesis that short-term treatment of mice with Type 2 diabetes mellitus (DM) with rosiglitazone (ROSI), an agonist of peroxisome proliferator-activated receptor-gamma, ameliorates the impaired coronary arteriolar dilation by reducing oxidative stress via a mechanism unrelated to its...

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Bibliografiske detaljer
Main Authors:	Bagi, Z, Koller, A, Kaley, G
Format:	Journal article
Sprog:	English
Udgivet:	2004

Lignende værker

PPAR gamma activation restores NO-Mediated dilations of coronary Arterioles in type 2 diabetes Mellitus
af: Bagi, Z, et al.
Udgivet: (2003)

Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus.
af: Bagi, Z, et al.
Udgivet: (2003)

Reduced sensitivity wall shear stress in arterioles of PECAM knockout mice due to impaired mechanotransduction
af: Bagi, Z, et al.
Udgivet: (2004)

Nitric oxide and hydrogen peroxide contribute to the development of reactive dilation in isolated coronary arterioles
af: Koller, A, et al.
Udgivet: (2004)

Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles.
af: Koller, A, et al.
Udgivet: (2004)

Hydrogen peroxide elicits COX-2-dependent production of constrictor prostaglandins in arterioles of type 2 diabetic mice
af: Bagi, Z, et al.
Udgivet: (2005)

Increased soluble guanylate cyclase (sGC) activity may compensate for the high fat diet-induced reduction in NO bioavailability of rat coronary arterioles
af: Koller, A, et al.
Udgivet: (2007)

Multiple effects of diabetes mellitus on the vasomotor responses of human coronary arterioles
af: Bagi, Z, et al.
Udgivet: (2007)

Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus.
af: Szerafin, T, et al.
Udgivet: (2006)

Aldose reductase inhibition reduces endothelial dysfunction and oxidative stress in skeletal muscle arterioles exposed to hyperglycemia
af: Toth, E, et al.
Udgivet: (2007)

Role of platelet endothelial adhesion molecule (PECAM)-1 in sensing and mediating high temporal gradients of shear stress in arterioles
af: Koller, A, et al.
Udgivet: (2006)

Oxidative stress via activating soluble guanylate cyclase leads to increased nitric oxide sensitivity of coronary arterioles in high fat diet-induced obesity
af: Erdei, N, et al.
Udgivet: (2007)

PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress.
af: Bagi, Z, et al.
Udgivet: (2005)

Increased activity of tissue ACE impairs dilation of coronary arterioles in obesity
af: Feher, A, et al.
Udgivet: (2011)

Conducted vasodilatation in human coronary arterioles
af: Bagi, Z, et al.
Udgivet: (2011)

Enhanced superoxide production reduces NO-mediation of flow-dependent dilation of isolated coronary arteries in type 2 diabetes mellitus
af: Bagi, Z, et al.
Udgivet: (2003)

High intraluminal pressure reduces tachyphylaxis to angiotensin II in isolated arterioles
af: Koller, A, et al.
Udgivet: (2006)

Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
af: Fulop, T, et al.
Udgivet: (2007)

PPAR gamma activation improves wall shear stress dependent regulation of coronary arteriolar diameter in type 2 diabetes mellitus
af: Bagi, Z, et al.
Udgivet: (2004)

Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia.
af: Ungvari, Z, et al.
Udgivet: (2000)

Impaired flow-induced dilation in skeletal muscle arterioles of rats with hyperhomocysteinemia (HHCY). Role of nitric oxide and constrictor prostanoids.
af: Bagi, Z, et al.
Udgivet: (2000)

Increased PGH(2)/TXA(2) synthesis in isolated arterioles and platelets of rats with hyperhomocysteinemia (HHCY).
af: Ungvari, Z, et al.
Udgivet: (2000)

Tetrahydrobiopterin (BH4) is essential for NO-mediated flow-dependent dilation of isolated skeletal muscle arterioles
af: Bagi, Z, et al.
Udgivet: (2003)

Asymmetric dimethylarginine (ADMA) increases the myogenic tone of arterioles due to enhanced release of superoxide
af: Toth, J, et al.
Udgivet: (2007)

Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.
af: Bagi, Z, et al.
Udgivet: (2001)

Type 2 diabetic mice have increased blood pressure and enhanced arteriolar basal tone due to COX-2-dependent TxA(2)/PGH(2) production
af: Bagi, Z, et al.
Udgivet: (2004)

Intrinsic vascular mechanisms stimulated by changes in pressure and now elicit reactive dilatation of isolated arterioles
af: Bagi, Z, et al.
Udgivet: (2000)

Upregulation of Arginase I Reduces Nitric Oxide-mediated Coronary Arteriolar Dilation in Patients With Type 2 Diabetes
af: Bagi, Z, et al.
Udgivet: (2009)

Lack of flow-mediated dilation and enhanced angiotensin II-induced constriction in skeletal muscle arterioles of lupus-prone autoimmune mice.
af: Bagi, Z, et al.
Udgivet: (2006)

Specific roles of COX-1 and COX-2 inhibitors to interfere with the regulation of microvascular resistance in normal mice and mice with type 2 diabetes mellitus
af: Bagi, Z, et al.
Udgivet: (2005)

High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.
af: Jebelovszki, E, et al.
Udgivet: (2008)

Oxidative stress contributes significantly to the development of cardiac pump dysfunction in hyperhomocysteinemia
af: Bagi, Z, et al.
Udgivet: (2004)

Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).
af: Bagi, Z, et al.
Udgivet: (2004)

Chronic renal failure leads to reduced flow-dependent dilation in isolated rat skeletal muscle arterioles due to lack of NO mediation.
af: Bagi, Z, et al.
Udgivet: (2003)

O-Linked-n-Acetylglucosamine Formation Reduces Nitric Oxide-Dependent Dilation in Arterioles Exposed to High Glucose Concentrations
af: Beleznai, T, et al.
Udgivet: (2008)

H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice.
af: Erdei, N, et al.
Udgivet: (2007)

Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins.
af: Bagi, Z, et al.
Udgivet: (2005)

Transient elevation of glucose concentration reduces NO-mediation of flow-induced arteriolar dilation due to interaction between superoxide and tetrahydrobiopterin (BH4)
af: Bagi, Z, et al.
Udgivet: (2004)

Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats
af: Zoltán Fontányi, et al.
Udgivet: (2021-05-01)

Overexpression of Arginase I Leads to Diminished Acetylcholine-Induced Coronary Arteriolar Dilation in Patients with Type 2 Diabetes Mellitus
af: Bagi, Z, et al.
Udgivet: (2009)