Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.
The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC)...
Main Authors: | Boulter, J, Schmitz, N, Sewell, A, Godkin, A, Bachmann, M, Gallimore, A |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2007
|
Similar Items
-
Microfluidic platform for characterizing TCR–pMHC interactions
by: Stockslager, Max Andrew, et al.
Published: (2019) -
CD8 helps TCR catch slippery self pMHC
by: Dushek, O, et al.
Published: (2018) -
Molecular dynamics simulations reveal canonical conformations in different pMHC/TCR interactions
by: Alba, J, et al.
Published: (2020) -
172 pMHC MD simulations of Knapp et al. 2015
by: Knapp, B
Published: (2015) -
Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
by: Egan, JR, et al.
Published: (2022)