Functional differences between proteasome subtypes
Four proteasome subtypes are commonly present in mammalian tissues: standard proteasomes, which contain the standard catalytic subunits β1, β2 and β5; immunoproteasomes containing the immuno-subunits β1i, β2i and β5i; and two intermediate proteasomes, containing a mix of standard and immuno-subunits...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2022
|
| _version_ | 1826310806604611584 |
|---|---|
| author | Abi Habib, J Lesenfants, J Vigneron, N Van den Eynde, BJ |
| author_facet | Abi Habib, J Lesenfants, J Vigneron, N Van den Eynde, BJ |
| author_sort | Abi Habib, J |
| collection | OXFORD |
| description | Four proteasome subtypes are commonly present in mammalian tissues: standard proteasomes, which contain the standard catalytic subunits β1, β2 and β5; immunoproteasomes containing the immuno-subunits β1i, β2i and β5i; and two intermediate proteasomes, containing a mix of standard and immuno-subunits. Recent studies revealed the expression of two tissue-specific proteasome subtypes in cortical thymic epithelial cells and in testes: thymoproteasomes and spermatoproteasomes. In this review, we describe the mechanisms that enable the ATP- and ubiquitin-dependent as well as the ATP- and ubiquitin-independent degradation of proteins by the proteasome. We focus on understanding the role of the different proteasome subtypes in maintaining protein homeostasis in normal physiological conditions through the ATP- and ubiquitin-dependent degradation of proteins. Additionally, we discuss the role of each proteasome subtype in the ATP- and ubiquitin-independent degradation of disordered proteins. We also discuss the role of the proteasome in the generation of peptides presented by MHC class I molecules and the implication of having different proteasome subtypes for the peptide repertoire presented at the cell surface. Finally, we discuss the role of the immunoproteasome in immune cells and its modulation as a potential therapy for autoimmune diseases. |
| first_indexed | 2024-03-07T07:57:28Z |
| format | Journal article |
| id | oxford-uuid:64ef53d3-0595-4b8d-8829-f77b3e864b59 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:57:28Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:64ef53d3-0595-4b8d-8829-f77b3e864b592023-09-01T16:25:45ZFunctional differences between proteasome subtypesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:64ef53d3-0595-4b8d-8829-f77b3e864b59EnglishSymplectic ElementsMDPI2022Abi Habib, JLesenfants, JVigneron, NVan den Eynde, BJFour proteasome subtypes are commonly present in mammalian tissues: standard proteasomes, which contain the standard catalytic subunits β1, β2 and β5; immunoproteasomes containing the immuno-subunits β1i, β2i and β5i; and two intermediate proteasomes, containing a mix of standard and immuno-subunits. Recent studies revealed the expression of two tissue-specific proteasome subtypes in cortical thymic epithelial cells and in testes: thymoproteasomes and spermatoproteasomes. In this review, we describe the mechanisms that enable the ATP- and ubiquitin-dependent as well as the ATP- and ubiquitin-independent degradation of proteins by the proteasome. We focus on understanding the role of the different proteasome subtypes in maintaining protein homeostasis in normal physiological conditions through the ATP- and ubiquitin-dependent degradation of proteins. Additionally, we discuss the role of each proteasome subtype in the ATP- and ubiquitin-independent degradation of disordered proteins. We also discuss the role of the proteasome in the generation of peptides presented by MHC class I molecules and the implication of having different proteasome subtypes for the peptide repertoire presented at the cell surface. Finally, we discuss the role of the immunoproteasome in immune cells and its modulation as a potential therapy for autoimmune diseases. |
| spellingShingle | Abi Habib, J Lesenfants, J Vigneron, N Van den Eynde, BJ Functional differences between proteasome subtypes |
| title | Functional differences between proteasome subtypes |
| title_full | Functional differences between proteasome subtypes |
| title_fullStr | Functional differences between proteasome subtypes |
| title_full_unstemmed | Functional differences between proteasome subtypes |
| title_short | Functional differences between proteasome subtypes |
| title_sort | functional differences between proteasome subtypes |
| work_keys_str_mv | AT abihabibj functionaldifferencesbetweenproteasomesubtypes AT lesenfantsj functionaldifferencesbetweenproteasomesubtypes AT vigneronn functionaldifferencesbetweenproteasomesubtypes AT vandeneyndebj functionaldifferencesbetweenproteasomesubtypes |