Synthesis of the anti-HIV agent (-)-hyperolactone C by using oxonium ylide formation-rearrangement.
Starting from readily available (S)-styrene oxide an asymmetric synthesis is described of the naturally occurring anti-HIV spirolactone (-)-hyperolactone C, which possesses adjacent fully substituted stereocenters. The key step involves a stereocontrolled Rh(II) -catalysed oxonium ylide formation-[2...
Full description
Bibliographic Details
| Main Authors: |
Hodgson, D,
Man, S |
|---|
| Format: | Journal article
|
|---|
| Language: | English |
|---|
| Published: |
2011
|
|---|