Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG)
Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy de...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2023
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| _version_ | 1797111279660302336 |
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| author | Baboumian, S Puma. L Swencionis, C Astbury, NM Ho, J Pantazatos, SP Geliebter, A |
| author_facet | Baboumian, S Puma. L Swencionis, C Astbury, NM Ho, J Pantazatos, SP Geliebter, A |
| author_sort | Baboumian, S |
| collection | OXFORD |
| description | Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal (p < 0.006 uncorrected) and stringent (p < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues (p < 0.006). BE (vs. NB) participants showed greater increases in the precuneus (p < 0.006) and thalamic regions (p < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus (p < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus (p < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments. |
| first_indexed | 2024-03-07T08:06:31Z |
| format | Journal article |
| id | oxford-uuid:652aeeea-591c-4ff4-a1d0-c2d1f163471d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:06:31Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:652aeeea-591c-4ff4-a1d0-c2d1f163471d2023-11-02T16:48:16ZBinge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:652aeeea-591c-4ff4-a1d0-c2d1f163471dEnglishSymplectic ElementsMDPI2023Baboumian, SPuma. LSwencionis, CAstbury, NMHo, JPantazatos, SPGeliebter, ABrain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal (p < 0.006 uncorrected) and stringent (p < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues (p < 0.006). BE (vs. NB) participants showed greater increases in the precuneus (p < 0.006) and thalamic regions (p < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus (p < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus (p < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments. |
| spellingShingle | Baboumian, S Puma. L Swencionis, C Astbury, NM Ho, J Pantazatos, SP Geliebter, A Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title | Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title_full | Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title_fullStr | Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title_full_unstemmed | Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title_short | Binge eating (BE) and obesity: brain activity and psychological measures before and after Roux-en-Y gastric bypass (RYBG) |
| title_sort | binge eating be and obesity brain activity and psychological measures before and after roux en y gastric bypass rybg |
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