APC mutations are sufficient for the growth of early colorectal adenomas.
It is not clear whether APC mutations are sufficient for early colorectal adenomas to grow or whether additional mutations at other loci are required. We previously have screened 210 early colorectal adenomas from familial adenomatous polyposis patients for mutations and allelic loss at APC. Here, w...
Κύριοι συγγραφείς: | Lamlum, H, Papadopoulou, A, Ilyas, M, Rowan, A, Gillet, C, Hanby, A, Talbot, I, Bodmer, W, Tomlinson, I |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2000
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Παρόμοια τεκμήρια
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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
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Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
ανά: Homfray, T, κ.ά.
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Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
ανά: Sieber, O, κ.ά.
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Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
ανά: Lamlum, H, κ.ά.
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Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
ανά: Thirlwell, C, κ.ά.
Έκδοση: (2007)