The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

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The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structur...

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Bibliographic Details
Main Authors:	Baumli, S, Lolli, G, Lowe, E, Troiani, S, Rusconi, L, Bullock, A, Debreczeni, J, Knapp, S, Johnson, L
Format:	Journal article
Language:	English
Published:	2008

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