A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling

A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling

Vascular remodeling to match arterial diameter to tissue requirements commonly fails in ischemic disease. Endothelial cells sense fluid shear stress (FSS) from blood flow to maintain FSS within a narrow range in healthy vessels. Thus, high FSS induces vessel outward remodeling, but mechanisms are po...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Springer Nature 2024

Ижил төстэй зүйлс

BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis
-н: Jacob D. Garritson, зэрэг
Хэвлэсэн: (2023-06-01)

KLF12 Aggravates Angiotensin II‐Induced Cardiac Remodeling in Male Mice by Transcriptionally Inhibiting SMAD7
-н: Min Hu, зэрэг
Хэвлэсэн: (2025-02-01)

SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
-н: Kuheli Banerjee, зэрэг
Хэвлэсэн: (2023-09-01)

High Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial Cells
-н: Hanqiang Deng, зэрэг
Хэвлэсэн: (2022-07-01)

BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells
-н: Fei Xiao, зэрэг
Хэвлэсэн: (2018-03-01)

Successfully Managed Respiratory Insufficiency in a Patient with a Novel Pathogenic Variant of the <i>BMPER</i> Gene: A Case Report
-н: Ho Eun Park, зэрэг
Хэвлэсэн: (2022-03-01)

Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription
-н: Jerome Jatzlau, зэрэг
Хэвлэсэн: (2023-09-01)

Creg1 Regulates Erythroid Development via TGF‐β/Smad2‐Klf1 Axis in Zebrafish
-н: Xiao Han, зэрэг
Хэвлэсэн: (2024-09-01)

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1
-н: Shuai Mei, зэрэг
Хэвлэсэн: (2024-11-01)

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1
-н: Shuai Mei, зэрэг
Хэвлэсэн: (2024-07-01)

Effect of Fluid Shear Stress on Portal Vein Remodeling in a Rat Model of Portal Hypertension
-н: Bin Wen, зэрэг
Хэвлэсэн: (2015-01-01)

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
-н: Nicolas Baeyens, зэрэг
Хэвлэсэн: (2015-02-01)

Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
-н: Paul-Lennard Mendez, зэрэг
Хэвлэсэн: (2022-09-01)

Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
-н: Odile Dumont, зэрэг
Хэвлэсэн: (2014-01-01)

The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
-н: Jun-Chen Li, зэрэг
Хэвлэсэн: (2021-01-01)

Fluid Shear Stress and Inner Curvature Remodeling of the Embryonic Heart. Choosing the Right Lane!
-н: Beerend P. Hierck, зэрэг
Хэвлэсэн: (2008-01-01)

Evolutionary Remodeling of Bacterial Motility Checkpoint Control
-н: Bin Ni, зэрэг
Хэвлэсэн: (2017-01-01)

The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice
-н: Cao Wang, зэрэг
Хэвлэсэн: (2023-02-01)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
-н: Adrien Bertrand-Chapel, зэрэг
Хэвлэсэн: (2022-10-01)

Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis
-н: Hiroaki Suzuki, зэрэг
Хэвлэсэн: (2023-08-01)

Pulsatile flow of shear-dependent fluid in a stenosed artery
-н: Mandal Shankar Mani, зэрэг
Хэвлэсэн: (2012-01-01)

Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway
-н: Myoung Sup Shim, зэрэг
Хэвлэсэн: (2023-12-01)

Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites
-н: Roman Tsaryk, зэрэг
Хэвлэсэн: (2022-03-01)

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway
-н: Jun Zhao, зэрэг
Хэвлэсэн: (2024-11-01)

Bioresponsive and immunotherapeutic nanomaterials to remodel tumor microenvironment for enhanced immune checkpoint blockade
-н: Tianxu Fang, зэрэг
Хэвлэсэн: (2024-02-01)

Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions
-н: Wang Lihua, зэрэг
Хэвлэсэн: (2023-04-01)

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension
-н: Yiqian Ban, зэрэг
Хэвлэсэн: (2019-02-01)

Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling
-н: Jiaxin Hu, зэрэг
Хэвлэсэн: (2023-08-01)

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart
-н: Xueyu Li, зэрэг
Хэвлэсэн: (2020-04-01)

The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy
-н: Siarhei A. Dabravolski, зэрэг
Хэвлэсэн: (2022-01-01)

Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques
-н: Antoniadis, Antonios P., зэрэг
Хэвлэсэн: (2017)

Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
-н: Mingkun Wang, зэрэг
Хэвлэсэн: (2023-04-01)

The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies.
-н: Ellen L van Agtmaal, зэрэг
Хэвлэсэн: (2012-01-01)

Lighting a Fire: Gasdermin-Mediated Pyroptosis Remodels the Glioma Microenvironment and Promotes Immune Checkpoint Blockade Response
-н: Yonghua Cai, зэрэг
Хэвлэсэн: (2022-06-01)

Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.
-н: Bevan, S, зэрэг
Хэвлэсэн: (1999)

The role of inflammatory mediators in renal vascular remodeling in patients with arterial hypertension
-н: E. S. Krutikov, зэрэг
Хэвлэсэн: (2014-10-01)

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling
-н: Davide M Coda, зэрэг
Хэвлэсэн: (2017-02-01)

SMAD proteins: Mediators of diverse outcomes during infection
-н: Lachlan Yuek Shun Lai, зэрэг
Хэвлэсэн: (2022-04-01)

Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
-н: Xiaoqing Fan, зэрэг
Хэвлэсэн: (2021-10-01)

Exploring the roles and therapeutic implications of melatonin-mediated KLF6 in the development of intracranial aneurysm
-н: Yan Liu, зэрэг
Хэвлэсэн: (2024-12-01)