Structural basis for inhibition of the fat mass and obesity associated protein (FTO).

Structural basis for inhibition of the fat mass and obesity associated protein (FTO).

The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid demethylase that acts on substrates including 3-methylthymidine, 3-methyluracil, and 6-methyladenine. To identify FTO inhibitors, we scree...

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Bibliographic Details
Main Authors:	Aik, W, Demetriades, M, Hamdan, M, Bagg, E, Yeoh, K, Lejeune, C, Zhang, Z, McDonough, M, Schofield, C
Format:	Journal article
Language:	English
Published:	2013

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