L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.

L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.

Transthyretin is a tetrameric protein associated with the commonest form of systemic amyloid disease. Using isotopically labeled proteins and mass spectrometry, we compared subunit exchange in wild-type transthyretin with that of the variant associated with the most aggressive form of the disease, L...

Полное описание

Библиографические подробности
Главные авторы:	Keetch, C, Bromley, E, McCammon, MG, Wang, N, Christodoulou, J, Robinson, C
Формат:	Journal article
Язык:	English
Опубликовано:	2005

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