ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk.
<h4>Background:</h4> <p>Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compar...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2015
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| _version_ | 1826276292831477760 |
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| author | Mincholé, A Bueno-Orovio, A Laguna, P Pueyo, E Rodriguez, B |
| author_facet | Mincholé, A Bueno-Orovio, A Laguna, P Pueyo, E Rodriguez, B |
| author_sort | Mincholé, A |
| collection | OXFORD |
| description | <h4>Background:</h4> <p>Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.</p> <h4>Methods and Results:</h4> <p>ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.</p> <h4>Conclusions:</h4> <p>This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.</p> |
| first_indexed | 2024-03-06T23:11:46Z |
| format | Journal article |
| id | oxford-uuid:65b7cbfe-5cec-4786-b1e3-b3be9e89972b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:11:46Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:65b7cbfe-5cec-4786-b1e3-b3be9e89972b2022-03-26T18:27:15ZECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:65b7cbfe-5cec-4786-b1e3-b3be9e89972bEnglishSymplectic Elements at OxfordElsevier2015Mincholé, ABueno-Orovio, ALaguna, PPueyo, ERodriguez, B<h4>Background:</h4> <p>Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.</p> <h4>Methods and Results:</h4> <p>ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.</p> <h4>Conclusions:</h4> <p>This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.</p> |
| spellingShingle | Mincholé, A Bueno-Orovio, A Laguna, P Pueyo, E Rodriguez, B ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title | ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title_full | ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title_fullStr | ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title_full_unstemmed | ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title_short | ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk. |
| title_sort | ecg based estimation of dispersion of apd restitution as a tool to stratify sotalol induced arrhythmic risk |
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