HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity

HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity

We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but indepe...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Gibbs-Seymour, I, Fontana, P, Rack, JGM, Ahel, I
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Cell Press 2016

Eitemau Tebyg

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
gan: Suskiewicz, MJ, et al.
Cyhoeddwyd: (2020)

Serine ADP-Ribosylation Depends on HPF1
gan: Bonfiglio, J, et al.
Cyhoeddwyd: (2017)

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
gan: Fa-Hui Sun, et al.
Cyhoeddwyd: (2021-02-01)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
gan: Kar, P, et al.
Cyhoeddwyd: (2024)

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
gan: Tatyana A. Kurgina, et al.
Cyhoeddwyd: (2021-11-01)

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
gan: Bilokapic, S, et al.
Cyhoeddwyd: (2020)

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
gan: Hiroshi Iwata, et al.
Cyhoeddwyd: (2016-10-01)

Mechanistic insights into the HPF1/PARP1 complex
gan: Zobel, FFH
Cyhoeddwyd: (2021)

(ADP-ribosyl)hydrolases: structure, function, and biology
gan: Rack, JGM, et al.
Cyhoeddwyd: (2020)

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
gan: M. M. Kutuzov, et al.
Cyhoeddwyd: (2021-03-01)

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
gan: Marie-France Langelier, et al.
Cyhoeddwyd: (2021-11-01)

Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase
gan: Liset Westera, et al.
Cyhoeddwyd: (2019-01-01)

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages
gan: Diego V. Santinelli-Pestana, et al.
Cyhoeddwyd: (2023-07-01)

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.
gan: Walter, I, et al.
Cyhoeddwyd: (2007)

PARP14: A key ADP-ribosylating protein in host-virus interactions?
gan: Srivatsan Parthasarathy, et al.
Cyhoeddwyd: (2022-06-01)

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs
gan: Maria Giulia Nizi, et al.
Cyhoeddwyd: (2023-08-01)

The PARP1/ARTD1-Mediated Poly-ADP-Ribosylation and DNA Damage Repair in B Cell Diversification
gan: Jackline J.M. Lasola, et al.
Cyhoeddwyd: (2014-01-01)

Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity.
gan: Schwerdtle, T, et al.
Cyhoeddwyd: (2007)

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
gan: Zhenzhen Li, et al.
Cyhoeddwyd: (2021-05-01)

Serine-linked PARP1 auto-modification controls PARP inhibitor response.
gan: Prokhorova, E, et al.
Cyhoeddwyd: (2021)

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
gan: Qian Chen, et al.
Cyhoeddwyd: (2018-08-01)

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment
gan: C. Maresca, et al.
Cyhoeddwyd: (2023-03-01)

Molecular tools for the study of ADP-ribosylation: a unified and versatile method to synthesise native mono-ADP-ribosylated peptides
gan: Voorneveld, J, et al.
Cyhoeddwyd: (2021)

High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
gan: Saurabh S. Dhakar, et al.
Cyhoeddwyd: (2024-02-01)

Reversible ADP-ribosylation of RNA
gan: Munnur, D, et al.
Cyhoeddwyd: (2019)

Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 protein regulates the function of regulatory T cells
gan: Luo, X, et al.
Cyhoeddwyd: (2015)

<it>In silico </it>characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)
gan: Dittmar Katharina, et al.
Cyhoeddwyd: (2005-10-01)

HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
gan: Johannes Rudolph, et al.
Cyhoeddwyd: (2021-03-01)

Serine-linked PARP1 auto-modification controls PARP inhibitor response
gan: Evgeniia Prokhorova, et al.
Cyhoeddwyd: (2021-07-01)

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
gan: Guillaume Gaullier, et al.
Cyhoeddwyd: (2020-01-01)

Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro
gan: Maria V. Sukhanova, et al.
Cyhoeddwyd: (2024-09-01)

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells
gan: Lianhua Piao, et al.
Cyhoeddwyd: (2014-03-01)

Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG
gan: Edoardo José Longarini, et al.
Cyhoeddwyd: (2024-05-01)

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
gan: Ivo A. Hendriks, et al.
Cyhoeddwyd: (2021-10-01)

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
gan: Pietro Fontana, et al.
Cyhoeddwyd: (2023-06-01)

In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation
gan: Angelica Aguilera-Gomez, et al.
Cyhoeddwyd: (2016-11-01)

Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS
gan: Ruiqi Chen, et al.
Cyhoeddwyd: (2024-03-01)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
gan: Natalya Maluchenko, et al.
Cyhoeddwyd: (2022-10-01)

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
gan: Rack, JGM, et al.
Cyhoeddwyd: (2021)

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
gan: Kira Schützenhofer, et al.
Cyhoeddwyd: (2021-11-01)