Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation.
Although oligoclonal banding is a characteristic feature of MS spinal fluid, some patients do not show this abnormality. Four of 18 consecutive patients with autopsy-proven MS had no oligoclonal bands (OB) in CSF during life or at postmortem. Patients with OB had numerous plasma cells in meninges an...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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1985
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| _version_ | 1826276314414317568 |
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| author | Farrell, M Kaufmann, J Gilbert, J Noseworthy, J Armstrong, H Ebers, G |
| author_facet | Farrell, M Kaufmann, J Gilbert, J Noseworthy, J Armstrong, H Ebers, G |
| author_sort | Farrell, M |
| collection | OXFORD |
| description | Although oligoclonal banding is a characteristic feature of MS spinal fluid, some patients do not show this abnormality. Four of 18 consecutive patients with autopsy-proven MS had no oligoclonal bands (OB) in CSF during life or at postmortem. Patients with OB had numerous plasma cells in meninges and plaques (confirmed in sections stained for cytoplasmic immunoglobulin). The four patients without bands had few or no identifiable plasma cells. Therefore, lack of OB correlates with both inactivity of plaques and absence of plasma cells in plaques or meninges. This is another form of heterogeneity in MS. |
| first_indexed | 2024-03-06T23:12:05Z |
| format | Journal article |
| id | oxford-uuid:65d62c4d-5742-4435-823d-884425b71aaa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:12:05Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:65d62c4d-5742-4435-823d-884425b71aaa2022-03-26T18:28:04ZOligoclonal bands in multiple sclerosis: clinical-pathologic correlation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:65d62c4d-5742-4435-823d-884425b71aaaEnglishSymplectic Elements at Oxford1985Farrell, MKaufmann, JGilbert, JNoseworthy, JArmstrong, HEbers, GAlthough oligoclonal banding is a characteristic feature of MS spinal fluid, some patients do not show this abnormality. Four of 18 consecutive patients with autopsy-proven MS had no oligoclonal bands (OB) in CSF during life or at postmortem. Patients with OB had numerous plasma cells in meninges and plaques (confirmed in sections stained for cytoplasmic immunoglobulin). The four patients without bands had few or no identifiable plasma cells. Therefore, lack of OB correlates with both inactivity of plaques and absence of plasma cells in plaques or meninges. This is another form of heterogeneity in MS. |
| spellingShingle | Farrell, M Kaufmann, J Gilbert, J Noseworthy, J Armstrong, H Ebers, G Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title | Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title_full | Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title_fullStr | Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title_full_unstemmed | Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title_short | Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation. |
| title_sort | oligoclonal bands in multiple sclerosis clinical pathologic correlation |
| work_keys_str_mv | AT farrellm oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation AT kaufmannj oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation AT gilbertj oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation AT noseworthyj oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation AT armstrongh oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation AT ebersg oligoclonalbandsinmultiplesclerosisclinicalpathologiccorrelation |