An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population

Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestr...

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Main Authors: Klein, A, Lindström, S, Mendelsohn, J, Steplowski, E, Arslan, A, Bueno-De-Mesquita, H, Fuchs, C, Gallinger, S, Gross, M, Helzlsouer, K, Holly, E, Jacobs, E, Lacroix, A, Li, D, Mandelson, M, Olson, S, Petersen, G, Risch, H, Stolzenberg-Solomon, R, Zheng, W, Amundadottir, L, Albanes, D, Allen, N, Bamlet, W, Boutron-Ruault, M, Buring, J, Bracci, P, Canzian, F, Clipp, S, Cotterchio, M, Duell, E, Elena, J, Gaziano, J, Giovannucci, E, Goggins, M, Hallmans, G, Hassan, M, Hutchinson, A, Hunter, D, Kooperberg, C, Kurtz, R, Liu, S, Overvad, K, Palli, D, Patel, A, Rabe, K, Shu, X, Slimani, N, Tobias, G, Trichopoulos, D, Van Den Eeden, S, Vineis, P, Virtamo, J, Wactawski-Wende, J, Wolpin, B, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Chanock, S, Hoover, R, Hartge, P, Kraft, P
格式: Journal article
語言:English
出版: Public Library of Science 2013
_version_ 1826276322186362880
author Klein, A
Lindström, S
Mendelsohn, J
Steplowski, E
Arslan, A
Bueno-De-Mesquita, H
Fuchs, C
Gallinger, S
Gross, M
Helzlsouer, K
Holly, E
Jacobs, E
Lacroix, A
Li, D
Mandelson, M
Olson, S
Petersen, G
Risch, H
Stolzenberg-Solomon, R
Zheng, W
Amundadottir, L
Albanes, D
Allen, N
Bamlet, W
Boutron-Ruault, M
Buring, J
Bracci, P
Canzian, F
Clipp, S
Cotterchio, M
Duell, E
Elena, J
Gaziano, J
Giovannucci, E
Goggins, M
Hallmans, G
Hassan, M
Hutchinson, A
Hunter, D
Kooperberg, C
Kurtz, R
Liu, S
Overvad, K
Palli, D
Patel, A
Rabe, K
Shu, X
Slimani, N
Tobias, G
Trichopoulos, D
Van Den Eeden, S
Vineis, P
Virtamo, J
Wactawski-Wende, J
Wolpin, B
Yu, H
Yu, K
Zeleniuch-Jacquotte, A
Chanock, S
Hoover, R
Hartge, P
Kraft, P
author_facet Klein, A
Lindström, S
Mendelsohn, J
Steplowski, E
Arslan, A
Bueno-De-Mesquita, H
Fuchs, C
Gallinger, S
Gross, M
Helzlsouer, K
Holly, E
Jacobs, E
Lacroix, A
Li, D
Mandelson, M
Olson, S
Petersen, G
Risch, H
Stolzenberg-Solomon, R
Zheng, W
Amundadottir, L
Albanes, D
Allen, N
Bamlet, W
Boutron-Ruault, M
Buring, J
Bracci, P
Canzian, F
Clipp, S
Cotterchio, M
Duell, E
Elena, J
Gaziano, J
Giovannucci, E
Goggins, M
Hallmans, G
Hassan, M
Hutchinson, A
Hunter, D
Kooperberg, C
Kurtz, R
Liu, S
Overvad, K
Palli, D
Patel, A
Rabe, K
Shu, X
Slimani, N
Tobias, G
Trichopoulos, D
Van Den Eeden, S
Vineis, P
Virtamo, J
Wactawski-Wende, J
Wolpin, B
Yu, H
Yu, K
Zeleniuch-Jacquotte, A
Chanock, S
Hoover, R
Hartge, P
Kraft, P
author_sort Klein, A
collection OXFORD
description Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates. Results Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84–2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19–1.76]), obesity (body mass index >30 kg/m2) (OR: 1.26 [1.09–1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13–2.18], case-control OR: 1.80 [1.40–2.32]), family history of pancreatic cancer (OR: 1.60 [1.20–2.12]), non-O ABO genotype (AO vs. OO genotype) (OR: 1.23 [1.10–1.37]) to (BB vs. OO genotype) (OR 1.58 [0.97–2.59]), rs3790844(chr1q32.1) (OR: 1.29 [1.19–1.40]), rs401681(5p15.33) (OR: 1.18 [1.10–1.26]) and rs9543325(13q22.1) (OR: 1.27 [1.18–1.36]). The areas under the ROC curve for risk models including only non-genetic factors, only genetic factors, and both non-genetic and genetic factors were 58%, 57% and 61%, respectively. We estimate that fewer than 3/1,000 U.S. non-Hispanic whites have more than a 5% predicted lifetime absolute risk. Conclusion Although absolute risk modeling using established risk factors may help to identify a group of individuals at higher than average risk of pancreatic cancer, the immediate clinical utility of our model is limited. However, a risk model can increase awareness of the various risk factors for pancreatic cancer, including modifiable behaviors.
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spelling oxford-uuid:65e15d4c-ac2e-46dd-845c-df1b2575ec572022-03-26T18:28:30ZAn absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general populationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:65e15d4c-ac2e-46dd-845c-df1b2575ec57EnglishSymplectic Elements at OxfordPublic Library of Science2013Klein, ALindström, SMendelsohn, JSteplowski, EArslan, ABueno-De-Mesquita, HFuchs, CGallinger, SGross, MHelzlsouer, KHolly, EJacobs, ELacroix, ALi, DMandelson, MOlson, SPetersen, GRisch, HStolzenberg-Solomon, RZheng, WAmundadottir, LAlbanes, DAllen, NBamlet, WBoutron-Ruault, MBuring, JBracci, PCanzian, FClipp, SCotterchio, MDuell, EElena, JGaziano, JGiovannucci, EGoggins, MHallmans, GHassan, MHutchinson, AHunter, DKooperberg, CKurtz, RLiu, SOvervad, KPalli, DPatel, ARabe, KShu, XSlimani, NTobias, GTrichopoulos, DVan Den Eeden, SVineis, PVirtamo, JWactawski-Wende, JWolpin, BYu, HYu, KZeleniuch-Jacquotte, AChanock, SHoover, RHartge, PKraft, PPurpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates. Results Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84–2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19–1.76]), obesity (body mass index >30 kg/m2) (OR: 1.26 [1.09–1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13–2.18], case-control OR: 1.80 [1.40–2.32]), family history of pancreatic cancer (OR: 1.60 [1.20–2.12]), non-O ABO genotype (AO vs. OO genotype) (OR: 1.23 [1.10–1.37]) to (BB vs. OO genotype) (OR 1.58 [0.97–2.59]), rs3790844(chr1q32.1) (OR: 1.29 [1.19–1.40]), rs401681(5p15.33) (OR: 1.18 [1.10–1.26]) and rs9543325(13q22.1) (OR: 1.27 [1.18–1.36]). The areas under the ROC curve for risk models including only non-genetic factors, only genetic factors, and both non-genetic and genetic factors were 58%, 57% and 61%, respectively. We estimate that fewer than 3/1,000 U.S. non-Hispanic whites have more than a 5% predicted lifetime absolute risk. Conclusion Although absolute risk modeling using established risk factors may help to identify a group of individuals at higher than average risk of pancreatic cancer, the immediate clinical utility of our model is limited. However, a risk model can increase awareness of the various risk factors for pancreatic cancer, including modifiable behaviors.
spellingShingle Klein, A
Lindström, S
Mendelsohn, J
Steplowski, E
Arslan, A
Bueno-De-Mesquita, H
Fuchs, C
Gallinger, S
Gross, M
Helzlsouer, K
Holly, E
Jacobs, E
Lacroix, A
Li, D
Mandelson, M
Olson, S
Petersen, G
Risch, H
Stolzenberg-Solomon, R
Zheng, W
Amundadottir, L
Albanes, D
Allen, N
Bamlet, W
Boutron-Ruault, M
Buring, J
Bracci, P
Canzian, F
Clipp, S
Cotterchio, M
Duell, E
Elena, J
Gaziano, J
Giovannucci, E
Goggins, M
Hallmans, G
Hassan, M
Hutchinson, A
Hunter, D
Kooperberg, C
Kurtz, R
Liu, S
Overvad, K
Palli, D
Patel, A
Rabe, K
Shu, X
Slimani, N
Tobias, G
Trichopoulos, D
Van Den Eeden, S
Vineis, P
Virtamo, J
Wactawski-Wende, J
Wolpin, B
Yu, H
Yu, K
Zeleniuch-Jacquotte, A
Chanock, S
Hoover, R
Hartge, P
Kraft, P
An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title_full An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title_fullStr An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title_full_unstemmed An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title_short An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
title_sort absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
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