MDM2 is a central node in the p53 pathway: 12 years and counting.
Twelve years ago, the Mdm2 oncogene was shown to bind to and inhibit the tumor suppressor protein, p53. During the past 12 years, both genetic and biochemical studies have demonstrated that Mdm2 is a key negative regulator of the tumor suppressor p53. Mdm2 and p53 form an oscillating auto-regulatory...
| Main Authors: | , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2005
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