Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).
A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-ce...
| Główni autorzy: | , , , , , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
1984
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| _version_ | 1826276346242793472 |
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| author | Waldmann, H Polliak, A Hale, G Or, R Cividalli, G Weiss, L Weshler, Z Samuel, S Manor, D Brautbar, C |
| author_facet | Waldmann, H Polliak, A Hale, G Or, R Cividalli, G Weiss, L Weshler, Z Samuel, S Manor, D Brautbar, C |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0.18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0.5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD. |
| first_indexed | 2024-03-06T23:12:34Z |
| format | Journal article |
| id | oxford-uuid:65fd303c-167a-4ddc-bc62-db8c36ca4c06 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:12:34Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:65fd303c-167a-4ddc-bc62-db8c36ca4c062022-03-26T18:29:06ZElimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:65fd303c-167a-4ddc-bc62-db8c36ca4c06EnglishSymplectic Elements at Oxford1984Waldmann, HPolliak, AHale, GOr, RCividalli, GWeiss, LWeshler, ZSamuel, SManor, DBrautbar, CA new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0.18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0.5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD. |
| spellingShingle | Waldmann, H Polliak, A Hale, G Or, R Cividalli, G Weiss, L Weshler, Z Samuel, S Manor, D Brautbar, C Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title | Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title_full | Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title_fullStr | Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title_full_unstemmed | Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title_short | Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). |
| title_sort | elimination of graft versus host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat anti human lymphocyte antibody campath 1 |
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