The immunopathology of thymic GVHD.
The clinical success of allogeneic hematopoietic stem cell transplantation (HSCT) depends on the appropriate reconstitution of the host's immune system. While recovery of T-cell immunity may occur in transplant recipients via both thymus-dependent and thymus-independent pathways, the regenerati...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797072780964921344 |
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| author | Krenger, W Holländer, G |
| author_facet | Krenger, W Holländer, G |
| author_sort | Krenger, W |
| collection | OXFORD |
| description | The clinical success of allogeneic hematopoietic stem cell transplantation (HSCT) depends on the appropriate reconstitution of the host's immune system. While recovery of T-cell immunity may occur in transplant recipients via both thymus-dependent and thymus-independent pathways, the regeneration of a population of phenotypically naive T cells with a broad receptor repertoire relies entirely on the de novo generation of T-cells in the thymus. Preclinical models and clinical studies of allogeneic HSCT have identified the thymus as a target of graft-versus-host disease (GVHD), thus limiting T-cell regeneration. The present review focuses on recent insight into how GVHD affects thymic structure and function and how this knowledge may aid in the design of new strategies to improve T-cell reconstitution following allogeneic HSCT. |
| first_indexed | 2024-03-06T23:12:39Z |
| format | Journal article |
| id | oxford-uuid:66068d2c-bc2c-48e4-985d-899fb7e3a7aa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:12:39Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:66068d2c-bc2c-48e4-985d-899fb7e3a7aa2022-03-26T18:29:17ZThe immunopathology of thymic GVHD.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:66068d2c-bc2c-48e4-985d-899fb7e3a7aaEnglishSymplectic Elements at Oxford2008Krenger, WHolländer, GThe clinical success of allogeneic hematopoietic stem cell transplantation (HSCT) depends on the appropriate reconstitution of the host's immune system. While recovery of T-cell immunity may occur in transplant recipients via both thymus-dependent and thymus-independent pathways, the regeneration of a population of phenotypically naive T cells with a broad receptor repertoire relies entirely on the de novo generation of T-cells in the thymus. Preclinical models and clinical studies of allogeneic HSCT have identified the thymus as a target of graft-versus-host disease (GVHD), thus limiting T-cell regeneration. The present review focuses on recent insight into how GVHD affects thymic structure and function and how this knowledge may aid in the design of new strategies to improve T-cell reconstitution following allogeneic HSCT. |
| spellingShingle | Krenger, W Holländer, G The immunopathology of thymic GVHD. |
| title | The immunopathology of thymic GVHD. |
| title_full | The immunopathology of thymic GVHD. |
| title_fullStr | The immunopathology of thymic GVHD. |
| title_full_unstemmed | The immunopathology of thymic GVHD. |
| title_short | The immunopathology of thymic GVHD. |
| title_sort | immunopathology of thymic gvhd |
| work_keys_str_mv | AT krengerw theimmunopathologyofthymicgvhd AT hollanderg theimmunopathologyofthymicgvhd AT krengerw immunopathologyofthymicgvhd AT hollanderg immunopathologyofthymicgvhd |