Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides

Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides

Aryl substituted 2,2,2-trifluorodiazoethanes undergo rhodium(II)-catalysed insertion reactions with tin hydrides affording the corresponding α-(trifluoromethyl)benzyl stannanes. This reactivity contrasts with that of diazo esters which predominantly afford CH2 reduction products in the presence of t...

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Dades bibliogràfiques
Autors principals: Hyde, S, Veliks, J, Ascough, D, Szpera, R, Paton, R, Gouverneur, V
Format: Journal article
Idioma:English
Publicat: Elsevier 2018
Descripció
Sumari:Aryl substituted 2,2,2-trifluorodiazoethanes undergo rhodium(II)-catalysed insertion reactions with tin hydrides affording the corresponding α-(trifluoromethyl)benzyl stannanes. This reactivity contrasts with that of diazo esters which predominantly afford CH2 reduction products in the presence of tin hydrides. The first example of asymmetric insertion into tin hydrides using diazo compounds is also described. In addition, this system extends to asymmetric germanium hydride and silane insertion.

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