Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen

Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen

Bibliographic Details
Main Authors:	Sanchez-Fernandez, E, Tarhonskaya, H, Al-Qahtani, K, Hopkinson, J, McCullagh, J, Candela-Lena, J, Schofield, C, Flashman, E
Format:	Journal article
Published:	2012

Similar Items

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.
by: Sánchez-Fernández, E, et al.
Published: (2013)

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.
by: Hopkinson, R, et al.
Published: (2010)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
by: Rose, N, et al.
Published: (2008)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
by: Rose, N, et al.
Published: (2008)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
by: Tarhonskaya, H
Published: (2014)

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
by: Tarhonskaya, H, et al.
Published: (2014)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
by: Tarhonskaya, H, et al.
Published: (2014)

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
by: Tarhonskaya, H, et al.
Published: (2014)

2-oxoglutarate-dependent oxygenases
by: Islam, M, et al.
Published: (2018)

Mechanisms of human histone and nucleic acid demethylases.
by: Walport, L, et al.
Published: (2012)

Mechanisms of human histone and nucleic acid demethylases
by: Walport, L, et al.
Published: (2012)

Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
by: Tarhonskaya, H, et al.
Published: (2017)

Recent progress in histone demethylase inhibitors
by: McAllister, T, et al.
Published: (2016)

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
by: Woon, E, et al.
Published: (2012)

The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.
by: Mantri, M, et al.
Published: (2011)

The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves
by: Al-Qahtani, K, et al.
Published: (2015)

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
by: Woon, E, et al.
Published: (2012)

In vitro enzyme assays for JmjC-domain-containing lysine histone demethylases (JmjC-KDMs)
by: Tarhonskaya, H, et al.
Published: (2018)

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
by: Hsu, K-F, et al.
Published: (2020)

Mechanistic studies on histone demethylases and related enzymes
by: Hopkinson, RJ
Published: (2013)

Mechanistic Studies on Histone Demethylases and Related Enzymes
by: Hopkinson, R
Published: (2013)

Targeting histone lysine demethylases - Progress, challenges, and the future.
by: Thinnes, C, et al.
Published: (2014)

The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
by: Hancock, R, et al.
Published: (2017)

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
by: Gerken, T, et al.
Published: (2007)

P58Towards understanding the effect of ischaemia on epigenetic regulation by the histone demethylases.
by: Hancock, R, et al.
Published: (2014)

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
by: Kuo-Feng Hsu, et al.
Published: (2021-01-01)

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.
by: Schiller, R, et al.
Published: (2014)

Dioxygen binding is controlled by the protein environment in non-heme FeII and 2-oxoglutarate oxygenases: a study on histone demethylase PHF8 and an ethylene-forming enzyme
by: Chaturvedi, SS, et al.
Published: (2023)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
by: Walport, L, et al.
Published: (2016)

Structure and mechanism guided identification of histone demethylase inhibitors
by: Schofield, C
Published: (2010)

Human histone demethylase KDM6B can catalyse sequential oxidations
by: Hopkinson, R, et al.
Published: (2018)

Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication
by: Harris, JM, et al.
Published: (2024)

Mechanistic studies on 2-oxoglutarate dependent oxygenases
by: Schofield, C, et al.
Published: (1999)

Inhibition of 2-oxoglutarate dependent oxygenases.
by: Rose, N, et al.
Published: (2011)

JmjC histone demethylases act as chromatin oxygen sensors
by: Michael Batie, et al.
Published: (2019-07-01)

Zn-ejection for the selective inhibition of JMJD2 histone demethylases
by: Sekirnik, R, et al.
Published: (2012)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
by: Akane Kawamura, et al.
Published: (2017-04-01)

Exploring the substrate scope of histone demethylases
by: Bonnici, J
Published: (2020)

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
by: Rotili, D, et al.
Published: (2014)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
by: Mantri, M, et al.
Published: (2012)