The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by direct binding of talin to the cytoplasmic tail of the beta integrin...
Päätekijät: | Anthis, N, Wegener, K, Ye, F, Kim, C, Goult, B, Lowe, E, Vakonakis, I, Bate, N, Critchley, DR, Ginsberg, M, Campbell, I |
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Aineistotyyppi: | Journal article |
Kieli: | English |
Julkaistu: |
2009
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