FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas

FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas

The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune response signatures and major histocompatibility complex class II (MHC II)...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Brown, P, Wong, K, Felce, S, Lyne, L, Spearman, H, Soilleux, E, Pedersen, L, Møller, M, Green, T, Gascoyne, D, Banham, A
التنسيق:	Journal article
اللغة:	English
منشور في:	Nature Publishing Group 2015

مواد مشابهة

FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures
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Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients
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Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.
حسب: Wong, K, وآخرون
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منشور في: (2007-06-01)

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Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement.
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Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas.
حسب: Nyman, H, وآخرون
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BCL-2 but not FOXP1, is an adverse risk factor in immunochemotherapy treated non-germinal center diffuse large B-cell lymphomas
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Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation.
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Strong expression of FOXP1 predicts for poor prognosis within the non-germinal centre subgroup of diffuse large B cell lymphoma
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Tumor-associated macrophages in diffuse large B-cell lymphoma
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t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma.
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The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells
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Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model
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Serologic detection of diffuse large B-cell lymphoma-associated antigens.
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Diffuse b-cell lymphoma
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Pathway activation patterns in diffuse large B-cell lymphomas.
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The FOXP3 transcription factor as a regulatory T-cell marker
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Prognostic impact of activated B-cell focused classification in diffuse large B-cell lymphoma patients treated with R-CHOP.
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FOXP3+ regulatory T cells as biomarkers in human malignancies.
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Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL.
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Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.
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