The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.

The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.

p38 mitogen-activated protein kinase (MAPK) stabilises pro-inflammatory mediator mRNAs by inhibiting AU-rich element (ARE)-mediated decay. We show that in bone-marrow derived murine macrophages tristetraprolin (TTP) is necessary for the p38 MAPK-sensitive decay of several pro-inflammatory mRNAs, inc...

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Autors principals:	Tudor, C, Marchese, F, Hitti, E, Aubareda, A, Rawlinson, L, Gaestel, M, Blackshear, P, Clark, A, Saklatvala, J, Dean, J
Format:	Journal article
Idioma:	English
Publicat:	2009

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