Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection.
BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and aft...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797072875669159936 |
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| author | Romero, A Lagging, M Westin, J Dhillon, A Dustin, L Pawlotsky, J Neumann, A Ferrari, C Missale, G Haagmans, B Schalm, S Zeuzem, S Negro, F Verheij-Hart, E Hellstrand, K |
| author_facet | Romero, A Lagging, M Westin, J Dhillon, A Dustin, L Pawlotsky, J Neumann, A Ferrari, C Missale, G Haagmans, B Schalm, S Zeuzem, S Negro, F Verheij-Hart, E Hellstrand, K |
| author_sort | Romero, A |
| collection | OXFORD |
| description | BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 levels decreased 6 weeks into treatment and remained low in patients with an SVR. By contrast, plasma levels of IP-10 rebounded in patients who had detectable HCV RNA after the completion of treatment. Using cutoff IP-10 levels of 150 and 600 pg/mL for predicting an SVR in patients infected with HCV genotype 1 yielded a specificity and sensitivity of 81% and 95%, respectively. CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment. |
| first_indexed | 2024-03-06T23:13:59Z |
| format | Journal article |
| id | oxford-uuid:66774806-bfab-4166-8740-848c8d27653f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:13:59Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:66774806-bfab-4166-8740-848c8d27653f2022-03-26T18:32:06ZInterferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:66774806-bfab-4166-8740-848c8d27653fEnglishSymplectic Elements at Oxford2006Romero, ALagging, MWestin, JDhillon, ADustin, LPawlotsky, JNeumann, AFerrari, CMissale, GHaagmans, BSchalm, SZeuzem, SNegro, FVerheij-Hart, EHellstrand, KBACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 levels decreased 6 weeks into treatment and remained low in patients with an SVR. By contrast, plasma levels of IP-10 rebounded in patients who had detectable HCV RNA after the completion of treatment. Using cutoff IP-10 levels of 150 and 600 pg/mL for predicting an SVR in patients infected with HCV genotype 1 yielded a specificity and sensitivity of 81% and 95%, respectively. CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment. |
| spellingShingle | Romero, A Lagging, M Westin, J Dhillon, A Dustin, L Pawlotsky, J Neumann, A Ferrari, C Missale, G Haagmans, B Schalm, S Zeuzem, S Negro, F Verheij-Hart, E Hellstrand, K Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title | Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title_full | Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title_fullStr | Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title_full_unstemmed | Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title_short | Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. |
| title_sort | interferon ifn gamma inducible protein 10 association with histological results viral kinetics and outcome during treatment with pegylated ifn alpha 2a and ribavirin for chronic hepatitis c virus infection |
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