Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection.
HIV-1-specific CD8(+) T cells are present in most HIV-1-infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV-specific T-cell response are largely unknown. The majority of HIV-2-infected people behave as long-term non-progressors whi...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797072877717028864 |
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| author | Leligdowicz, A Onyango, C Yindom, L Peng, Y Cotten, M Jaye, A McMichael, A Whittle, H Dong, T Rowland-Jones, S |
| author_facet | Leligdowicz, A Onyango, C Yindom, L Peng, Y Cotten, M Jaye, A McMichael, A Whittle, H Dong, T Rowland-Jones, S |
| author_sort | Leligdowicz, A |
| collection | OXFORD |
| description | HIV-1-specific CD8(+) T cells are present in most HIV-1-infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV-specific T-cell response are largely unknown. The majority of HIV-2-infected people behave as long-term non-progressors while those who progress to AIDS do so in a manner indistinguishable from HIV-1. A detailed study of HIV-2 infection may identify protective immune responses. Robust gag p26-specific T-cell responses are elicited during HIV-2 infection and correlate with control of viremia. In this study, we analyzed features of an HLA-B 3501-restricted T-cell response to HIV-2 p26 that may contribute to virus control. In contrast to HIV-1, HIV-2-specific T cells are at an early stage of differentiation (CD27(+)CD28(+)), a finding that relates directly to CD4(+) T-cell levels and inversely to immune activation. The cells demonstrate IFN-gamma secretion, oligoclonal T-cell receptor Vbeta gene segment usage, exceptional avidity and secretion of pro-inflammatory cytokines. Despite the potentially strong selection pressure imposed on the virus by these cells, there was no evidence of HIV-2 sequence evolution. We propose that in chronic HIV-2 infection, the maintenance of early-differentiated, highly avid CD8(+) T cells could account for the non-progressive course of disease. Such responses may be desirable from an HIV vaccine. |
| first_indexed | 2024-03-06T23:14:01Z |
| format | Journal article |
| id | oxford-uuid:667a7276-2b60-42b9-ad2b-9412a3787764 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:14:01Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:667a7276-2b60-42b9-ad2b-9412a37877642022-03-26T18:32:10ZHighly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:667a7276-2b60-42b9-ad2b-9412a3787764EnglishSymplectic Elements at Oxford2010Leligdowicz, AOnyango, CYindom, LPeng, YCotten, MJaye, AMcMichael, AWhittle, HDong, TRowland-Jones, SHIV-1-specific CD8(+) T cells are present in most HIV-1-infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV-specific T-cell response are largely unknown. The majority of HIV-2-infected people behave as long-term non-progressors while those who progress to AIDS do so in a manner indistinguishable from HIV-1. A detailed study of HIV-2 infection may identify protective immune responses. Robust gag p26-specific T-cell responses are elicited during HIV-2 infection and correlate with control of viremia. In this study, we analyzed features of an HLA-B 3501-restricted T-cell response to HIV-2 p26 that may contribute to virus control. In contrast to HIV-1, HIV-2-specific T cells are at an early stage of differentiation (CD27(+)CD28(+)), a finding that relates directly to CD4(+) T-cell levels and inversely to immune activation. The cells demonstrate IFN-gamma secretion, oligoclonal T-cell receptor Vbeta gene segment usage, exceptional avidity and secretion of pro-inflammatory cytokines. Despite the potentially strong selection pressure imposed on the virus by these cells, there was no evidence of HIV-2 sequence evolution. We propose that in chronic HIV-2 infection, the maintenance of early-differentiated, highly avid CD8(+) T cells could account for the non-progressive course of disease. Such responses may be desirable from an HIV vaccine. |
| spellingShingle | Leligdowicz, A Onyango, C Yindom, L Peng, Y Cotten, M Jaye, A McMichael, A Whittle, H Dong, T Rowland-Jones, S Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title | Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title_full | Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title_fullStr | Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title_full_unstemmed | Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title_short | Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. |
| title_sort | highly avid oligoclonal early differentiated antigen specific cd8 t cells in chronic hiv 2 infection |
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