The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic lysosomal proteins, which lead to abnormal storage of macromolecular subst...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797072882016190464 |
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| author | Platt, F Boland, B van der Spoel, A |
| author_facet | Platt, F Boland, B van der Spoel, A |
| author_sort | Platt, F |
| collection | OXFORD |
| description | Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic lysosomal proteins, which lead to abnormal storage of macromolecular substrates. Valuable insights into lysosome functions have emerged from research into these diseases. In addition to primary lysosomal dysfunction, cellular pathways associated with other membrane-bound organelles are perturbed in these disorders. Through selective examples, we illustrate why the term "cellular storage disorders" may be a more appropriate description of these diseases and discuss therapies that can alleviate storage and restore normal cellular function. |
| first_indexed | 2024-03-06T23:14:05Z |
| format | Journal article |
| id | oxford-uuid:667f8952-52f0-4c9a-a752-014c3185c086 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:14:05Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:667f8952-52f0-4c9a-a752-014c3185c0862022-03-26T18:32:18ZThe cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:667f8952-52f0-4c9a-a752-014c3185c086EnglishSymplectic Elements at Oxford2012Platt, FBoland, Bvan der Spoel, ALysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic lysosomal proteins, which lead to abnormal storage of macromolecular substrates. Valuable insights into lysosome functions have emerged from research into these diseases. In addition to primary lysosomal dysfunction, cellular pathways associated with other membrane-bound organelles are perturbed in these disorders. Through selective examples, we illustrate why the term "cellular storage disorders" may be a more appropriate description of these diseases and discuss therapies that can alleviate storage and restore normal cellular function. |
| spellingShingle | Platt, F Boland, B van der Spoel, A The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title | The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title_full | The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title_fullStr | The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title_full_unstemmed | The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title_short | The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. |
| title_sort | cell biology of disease lysosomal storage disorders the cellular impact of lysosomal dysfunction |
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