FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE

Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.

Manylion Llyfryddiaeth
Prif Awduron: Baldwin, J, Blackburn, J, Sako, M, Schofield, C
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 1989
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author Baldwin, J
Blackburn, J
Sako, M
Schofield, C
author_facet Baldwin, J
Blackburn, J
Sako, M
Schofield, C
author_sort Baldwin, J
collection OXFORD
description Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.
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format Journal article
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institution University of Oxford
language English
last_indexed 2024-03-06T23:14:37Z
publishDate 1989
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spelling oxford-uuid:66b2c8a9-3b10-462f-b68e-dee8b3b91e3a2022-03-26T18:33:37ZFORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASEJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:66b2c8a9-3b10-462f-b68e-dee8b3b91e3aEnglishSymplectic Elements at Oxford1989Baldwin, JBlackburn, JSako, MSchofield, CIncubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.
spellingShingle Baldwin, J
Blackburn, J
Sako, M
Schofield, C
FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title_full FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title_fullStr FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title_full_unstemmed FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title_short FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
title_sort formation of a novel bicyclic gamma lactam with isopenicillin n synthase
work_keys_str_mv AT baldwinj formationofanovelbicyclicgammalactamwithisopenicillinnsynthase
AT blackburnj formationofanovelbicyclicgammalactamwithisopenicillinnsynthase
AT sakom formationofanovelbicyclicgammalactamwithisopenicillinnsynthase
AT schofieldc formationofanovelbicyclicgammalactamwithisopenicillinnsynthase