FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1826276482808283136 |
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| author | Baldwin, J Blackburn, J Sako, M Schofield, C |
| author_facet | Baldwin, J Blackburn, J Sako, M Schofield, C |
| author_sort | Baldwin, J |
| collection | OXFORD |
| description | Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage. |
| first_indexed | 2024-03-06T23:14:37Z |
| format | Journal article |
| id | oxford-uuid:66b2c8a9-3b10-462f-b68e-dee8b3b91e3a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:14:37Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:66b2c8a9-3b10-462f-b68e-dee8b3b91e3a2022-03-26T18:33:37ZFORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASEJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:66b2c8a9-3b10-462f-b68e-dee8b3b91e3aEnglishSymplectic Elements at Oxford1989Baldwin, JBlackburn, JSako, MSchofield, CIncubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage. |
| spellingShingle | Baldwin, J Blackburn, J Sako, M Schofield, C FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title | FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title_full | FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title_fullStr | FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title_full_unstemmed | FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title_short | FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE |
| title_sort | formation of a novel bicyclic gamma lactam with isopenicillin n synthase |
| work_keys_str_mv | AT baldwinj formationofanovelbicyclicgammalactamwithisopenicillinnsynthase AT blackburnj formationofanovelbicyclicgammalactamwithisopenicillinnsynthase AT sakom formationofanovelbicyclicgammalactamwithisopenicillinnsynthase AT schofieldc formationofanovelbicyclicgammalactamwithisopenicillinnsynthase |