FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE

Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.

Bibliográfalaš dieđut
Váldodahkkit:	Baldwin, J, Blackburn, J, Sako, M, Schofield, C
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	1989

Geahča maid

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1988)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
Dahkki: Randall, C, et al.
Almmustuhtton: (1992)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
Dahkki: Rabe, P, et al.
Almmustuhtton: (2018)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1992)

ENZYMATIC-SYNTHESIS OF BICYCLIC GAMMA-LACTAMS USING CLAVAMINIC ACID SYNTHASE
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1992)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Dahkki: Roach, P, et al.
Almmustuhtton: (1997)

Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1997)

SYNTHESIS OF A NOVEL BICYCLIC GAMMA-LACTAM ANALOG OF THE 1-OXAPENAMS
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1989)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1992)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1993)

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
Dahkki: Sami, M, et al.
Almmustuhtton: (1997)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
Dahkki: Aplin, RT, et al.
Almmustuhtton: (1990)

Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins
Dahkki: Cavelier, F, et al.
Almmustuhtton: (1997)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
Dahkki: Dubus, A, et al.
Almmustuhtton: (2000)

Mechanistic studies on isopenicillin n synthase
Dahkki: Abbott, S
Almmustuhtton: (1991)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
Dahkki: Roach, P, et al.
Almmustuhtton: (1995)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
Dahkki: Daruzzaman, A, et al.
Almmustuhtton: (2013)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
Dahkki: Roach, P, et al.
Almmustuhtton: (1995)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
Dahkki: Fujishima, Y, et al.
Almmustuhtton: (1994)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
Dahkki: Randall, C, et al.
Almmustuhtton: (1993)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
Dahkki: Roach, P, et al.
Almmustuhtton: (1996)

Modification of iron binding ligands in isopenicillin n synthase
Dahkki: Sami, M, et al.
Almmustuhtton: (1998)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
Dahkki: Ge, W, et al.
Almmustuhtton: (2010)

Photoaffinity labelling of isopenicillin N synthetase.
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1990)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
Dahkki: Ge, W, et al.
Almmustuhtton: (2010)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
Dahkki: Long, A, et al.
Almmustuhtton: (2003)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
Dahkki: Ge, W, et al.
Almmustuhtton: (2009)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
Dahkki: Roach, P, et al.
Almmustuhtton: (1996)

Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis.
Dahkki: Warren R Francis, et al.
Almmustuhtton: (2015-01-01)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1985)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1986)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1989)

Production of functionally active <it>Penicillium chrysogenum </it>isopenicillin N synthase in the yeast <it>Hansenula polymorpha</it>
Dahkki: Veenhuis Marten, et al.
Almmustuhtton: (2008-03-01)

THE SYNTHESIS OF POTENTIAL GAMMA-LACTAM ANTIBIOTICS CONTAINING A CYCLOSERINE NUCLEUS
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1990)

A GAMMA-LACTAM ANALOG OF PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
Dahkki: Baldwin, J, et al.
Almmustuhtton: (1986)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
Dahkki: Aplin, RT, et al.
Almmustuhtton: (1993)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
Dahkki: Clifton, I, et al.
Almmustuhtton: (2011)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
Dahkki: Rabe, P, et al.
Almmustuhtton: (2022)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
Dahkki: Long, A, et al.
Almmustuhtton: (2005)