Sequential open-label study of the safety, tolerability, and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults

Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. New antimalarial compounds will n...

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Autori principali: Hanboonkunupakarn, B, Van Der Pluijm, R, Hoglund, R, Pukrittayakamee, S, Winterberg, M, Mukaka, M, Waithira, N, Chotivanich, K, Singhasivanon, P, White, N, Dondorp, A, Tarning, J, Jittamala, P
Natura: Journal article
Lingua:English
Pubblicazione: American Society for Microbiology 2019