Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo

Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo

The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome character...

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Bibliografiske detaljer
Main Authors:	O'Neil, JD, Ross, EA, Ridley, ML, Ding, Q, Tang, T, Rosner, DR, Crowley, T, Malhi, D, Dean, JL, Smallie, T, Buckley, CD, Clark, AR
Format:	Journal article
Sprog:	English
Udgivet:	American Society for Microbiology 2017

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