Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo

Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro yet has overwhelmingly anti-inflammatory consequences in vivo

The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome character...

Bibliografske podrobnosti
Main Authors:	O'Neil, JD, Ross, EA, Ridley, ML, Ding, Q, Tang, T, Rosner, DR, Crowley, T, Malhi, D, Dean, JL, Smallie, T, Buckley, CD, Clark, AR
Format:	Journal article
Jezik:	English
Izdano:	American Society for Microbiology 2017

Podobne knjige/članki

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression
od: Ross, E, et al.
Izdano: (2016)

Has Humankind Overwhelmed Nature’s Agency?
od: Williams James
Izdano: (2022-12-01)

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin
od: Tina Tang, et al.
Izdano: (2017-06-01)

College of the Overwhelmed
od: Denise L. Rode
Izdano: (2006-06-01)

Role of Tristetraprolin in the Resolution of Inflammation
od: Peter Rappl, et al.
Izdano: (2021-01-01)

The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself.
od: Tchen, C, et al.
Izdano: (2004)

The overwhelming prevalence of suffering in Nature
od: Alejandro Villamor Iglesias
Izdano: (2018-02-01)

Overwhelming bone marrow Leishmaniasis
od: Raihan Sajid, et al.
Izdano: (2011-12-01)

Overwhelming bone marrow Leishmaniasis
od: Raihan Sajid, et al.
Izdano: (2011-12-01)

Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors
od: Won Hyeok Lee, et al.
Izdano: (2020-08-01)

«Such army Poland has not had yet»
od: Taras Kovalets
Izdano: (2022-06-01)

«Such army Poland has not had yet»
od: Тарас Ковалець
Izdano: (2022-06-01)

Overwhelming Complexities: Between Rome and Jerusalem
od: Duarte de Oliveira Manuel
Izdano: (2023-12-01)

Overwhelming Asplenic Sepsis due to Babesiosis
od: Chakra P. Chaulagain
Izdano: (2019-11-01)

Could humanity’s hoofprint overwhelm nature?
od: Philip Lymbery
Izdano: (2019-12-01)

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
od: Marie-Laure Arotcarena, et al.
Izdano: (2019-06-01)

An overwhelming post-splenectomy infection (OPSI)
od: Elbadawi O, et al.
Izdano: (2012-09-01)

Overcoming being Overwhelmed in the Trump Era
od: Navyug Gill
Izdano: (2017-05-01)

Overcoming Being Overwhelmed in the Trump Era
od: Navyug Gill
Izdano: (2019-02-01)

Overwhelming research during COVID-19
od: Christiaan Yu, et al.
Izdano: (2020-01-01)

Intravenous immunoglobulin for overwhelming postsplenectomy infection
od: Kensuke Nakamura, et al.
Izdano: (2021-01-01)

Tristetraprolin mediates immune evasion of mycobacterial infection in macrophages
od: Jiawei Wei, et al.
Izdano: (2024-08-01)

Tristetraprolin expression by keratinocytes protects against skin carcinogenesis
od: Assiya Assabban, et al.
Izdano: (2021-03-01)

Overwhelming Sepsis after a Cat Bite
od: Julie Blackburn, et al.
Izdano: (2013-01-01)

The Overwhelming Postsplenectomy Sepsis: Role of Plastic Surgeon
od: Marta Starnoni, MD, et al.
Izdano: (2023-07-01)

Australian Tropical Marine Micromolluscs: An Overwhelming Bias
od: Peter U. Middelfart, et al.
Izdano: (2016-08-01)

Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery
od: Ashara Kalpesh C., et al.
Izdano: (2017-03-01)

Pacific journalism solidarity in the face of overwhelming forces
od: Fred Wesley
Izdano: (2020-07-01)

Identification of target mRNAs regulated by both p38 MAPK and tristetraprolin in murine macrophages
od: Tudor, C, et al.
Izdano: (2007)

Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin
od: Pavel Kovarik, et al.
Izdano: (2021-09-01)

Resveratrol attenuates inflammation through tristetraprolin expression in human hepatocytes
od: Akhi Moni; Asif Iqbal; Md Jamal Uddin
Izdano: (2018-12-01)

Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin
od: Yong Wun Cho, et al.
Izdano: (2014-12-01)

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis
od: Chune Ren, et al.
Izdano: (2018-05-01)

The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet.
od: Sarah J Glastras, et al.
Izdano: (2017-01-01)

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression.
od: Iqbal, M, et al.
Izdano: (2014)

The case against exchange transfusion has yet to be proved.
od: Koh, G, et al.
Izdano: (2014)

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
od: Sara Scinicariello, et al.
Izdano: (2023-03-01)

Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages.
od: Dipankar Ray, et al.
Izdano: (2013-01-01)

hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
od: Boris Reznik, et al.
Izdano: (2014-01-01)

Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells
od: Kyu Hwan Kwack, et al.
Izdano: (2022-10-01)