HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China
<p><strong>Objective:</strong> This study aims to investigate the distribution of HLA-A genes and identify alleles related to cervical cancer.</p> <p><strong>Materials and Methods:</strong> A total of 252 cervical cancer patients (56 Han ethnic and 196 Uyghu...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Medknow Publications
2018
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| _version_ | 1797072954164510720 |
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| author | Alifu, M Hu, Y Dong, T Wang, R |
| author_facet | Alifu, M Hu, Y Dong, T Wang, R |
| author_sort | Alifu, M |
| collection | OXFORD |
| description | <p><strong>Objective:</strong> This study aims to investigate the distribution of HLA-A genes and identify alleles related to cervical cancer.</p> <p><strong>Materials and Methods:</strong> A total of 252 cervical cancer patients (56 Han ethnic and 196 Uyghur ethnic) and 213 controls (103 Han ethnic and 110 Uyghur ethnic) were recruited in this study. HLA-A alleles were examined by polymerase chain reaction with sequence-specific primers. The frequencies of different HLA-A alleles were compared between the two ethnic groups as well as patients and controls. The correlation of HLA-A frequencies with various clinical characteristics and short-term treatment efficacy was analyzed.</p> <p><strong>Results:</strong> (1) Significantly higher frequencies of HLA-A*03:01 and HLA-A*03:02 and lower frequencies of HLA-A*11:01, HLA-A*24:02, and HLA-A*30:01 were observed in the Uyghur control groups than in Han control groups (P ≤ 0.05). (2) The frequency of HLA-A*01:01 in patients was significantly higher than controls. In contrast, the frequencies of HLA-A*30:01 and HLA-A*33:03 were lower in patients (P ≤ 0.05). (3) The frequency of HLA-A*30:01 in Han patients was lower than Han control group (P ≤ 0.05). However, there was no statistically significant in the frequency of HLA-A between Uyghur patients and controls (P > 0.05). (4) There was no significant association between HLA-A alleles and HPV16 or squamous cell carcinoma antigen levels (P > 0.05). (5) The frequency of HLA-A*30:01 allele in complete response + partial response group was higher than stable disease + progressive disease group (P ≤ 0.05).</p> <p><strong>Conclusions:</strong> People from two ethnic groups displayed different HLA-A gene distribution. HLA-A*30:01 and HLA-A*33:03 alleles are the protective factors to cervical cancer patients from Xinjiang while HLA-A*01:01 serves as the susceptible gene.</p> |
| first_indexed | 2024-03-06T23:15:06Z |
| format | Journal article |
| id | oxford-uuid:66dc3e6c-feb7-4bf4-8f5a-0e1c534d9185 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:15:06Z |
| publishDate | 2018 |
| publisher | Medknow Publications |
| record_format | dspace |
| spelling | oxford-uuid:66dc3e6c-feb7-4bf4-8f5a-0e1c534d91852022-03-26T18:34:37ZHLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, ChinaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:66dc3e6c-feb7-4bf4-8f5a-0e1c534d9185EnglishSymplectic Elements at OxfordMedknow Publications2018Alifu, MHu, YDong, TWang, R<p><strong>Objective:</strong> This study aims to investigate the distribution of HLA-A genes and identify alleles related to cervical cancer.</p> <p><strong>Materials and Methods:</strong> A total of 252 cervical cancer patients (56 Han ethnic and 196 Uyghur ethnic) and 213 controls (103 Han ethnic and 110 Uyghur ethnic) were recruited in this study. HLA-A alleles were examined by polymerase chain reaction with sequence-specific primers. The frequencies of different HLA-A alleles were compared between the two ethnic groups as well as patients and controls. The correlation of HLA-A frequencies with various clinical characteristics and short-term treatment efficacy was analyzed.</p> <p><strong>Results:</strong> (1) Significantly higher frequencies of HLA-A*03:01 and HLA-A*03:02 and lower frequencies of HLA-A*11:01, HLA-A*24:02, and HLA-A*30:01 were observed in the Uyghur control groups than in Han control groups (P ≤ 0.05). (2) The frequency of HLA-A*01:01 in patients was significantly higher than controls. In contrast, the frequencies of HLA-A*30:01 and HLA-A*33:03 were lower in patients (P ≤ 0.05). (3) The frequency of HLA-A*30:01 in Han patients was lower than Han control group (P ≤ 0.05). However, there was no statistically significant in the frequency of HLA-A between Uyghur patients and controls (P > 0.05). (4) There was no significant association between HLA-A alleles and HPV16 or squamous cell carcinoma antigen levels (P > 0.05). (5) The frequency of HLA-A*30:01 allele in complete response + partial response group was higher than stable disease + progressive disease group (P ≤ 0.05).</p> <p><strong>Conclusions:</strong> People from two ethnic groups displayed different HLA-A gene distribution. HLA-A*30:01 and HLA-A*33:03 alleles are the protective factors to cervical cancer patients from Xinjiang while HLA-A*01:01 serves as the susceptible gene.</p> |
| spellingShingle | Alifu, M Hu, Y Dong, T Wang, R HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title | HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title_full | HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title_fullStr | HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title_full_unstemmed | HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title_short | HLA-A*30:01 and HLA-A*33:03 are the protective alleles while HLA-A*01:01 serves as the susceptible gene for cervical cancer patients in Xinjiang, China |
| title_sort | hla a 30 01 and hla a 33 03 are the protective alleles while hla a 01 01 serves as the susceptible gene for cervical cancer patients in xinjiang china |
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